ArticleEvidence-based complementary and alternative medicine : eCAM2013
Proanthocyanidin Attenuation of Oxidative Stress and NF- κ B Protects Apolipoprotein E-Deficient Mice against Diabetic Nephropathy.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- The pathogenesis of diabetic kidney disease and the therapeutic potential of bioactive substances.Frontiers in pharmacology · 2025Review
- Proanthocyanidin offers protection against diabetic nephropathy: elucidation of its mechanism of action using animal models.Pharmaceutical biology · 2024Review
- Promising Phytogenic Feed Additives Used as Anti-Mycotoxin Solutions in Animal Nutrition.Toxins · 2024Review
- Health Effects of Grape Seed and Skin Extracts and Their Influence on Biochemical Markers.Molecules (Basel, Switzerland) · 2020Review
- Intermittent Hypoxia Composite Abnormal Glucose Metabolism-Mediated AtherosclerosisOxidative medicine and cellular longevity · 2019Article
- Codonopsis tangshen Oliv. Amelioration Effect on Diabetic Kidney Disease Rats Induced by High Fat Diet Feeding Combined with Streptozotocin.Natural products and bioprospecting · 2018Article
- Corilagin Reduces the Frequency of Seizures and Improves Cognitive Function in a Rat Model of Chronic Epilepsy.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Effects of grape seed proanthocyanidin extract on pentylenetetrazole-induced kindling and associated cognitive impairment in rats.International journal of molecular medicine · 2014Article
- Effect of benazepril on the transdifferentiation of renal tubular epithelial cells from diabetic rats.Biomedical reports · 2014Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperlipidemia and hyperglycemia result in oxidative stress and play a major role in the development of diabetic nephropathy (DN). We explored the effects of proanthocyanidin (PA) on the induction and progression of DN in apolipoprotein E-deficient mice. Diabetes Mellitus was induced in ten-week-old male apoE(-/-)mice using streptozotocin (STZ). Mice were fed with a high-fat diet in presence or absence of PA. PA treatment significantly reduced the high cholesterol levels, restored renal functions, and reduced albuminuria in the PA-treated diabetic mice compared with the diabetic untreated mice. In addition, the glomerular mesangial expansion in the diabetic mice was attenuated as a result of PA supplementation. Moreover, PA treatment restored the elevated levels of MDA and CML and the reduced activity of SOD and GSH in the diabetic mice. Furthermore, PA feeding reduced the activation and translocation of NF- κ B to the nucleus compared with the diabetic untreated animals. Reduction of NF- κ B activation resulted in the attenuation of the expression of IL-6, TGF β , and RAGE which protected PA-treated mice against DN. The renoprotective effects of PA were found to be time independent regardless of whether the dietary feeding with PA was started pre-, co-, or post-STZ injection. In conclusion, part of the beneficial effects of PA includes the disruption of the detrimental AGE-RAGE-NF κ B pathways.
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Registered trials
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