Evidence map›Paper›PMID 24023525›Full record

ArticlePharmaceuticals (Basel, Switzerland)2010

Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer.

Adam C Reese, Jill Hardin, Iona Cheng, Graham Casey, John S Witte

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Adam C ReeseDepartment of Urology, University of California at San Francisco, 1450 3 Street, San Francisco, CA 94158, USA.
Jill Hardin
Iona Cheng
Graham Casey
John S Witte
University of California, San Francisco · USCancer Research Center · USUniversity of Southern California · US

Funding

Genetic Epidemiology of Prostate Cancer Risk and ProgressionR01CA088164 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAN DEN EEDEN, STEPHEN K., WITTE, JOHN S. · 2000 to 2015
$6.1M
Genomewide Association Study of Prostate CancerU01CA127298 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTE, JOHN S. · 2008 to 2012
$5.1M
NCI NIH HHS R01 CA088164NCI NIH HHS U01 CA127298
6 · The paper itself

Abstract

Increasing evidence suggests that prostatic inflammation plays a key role in the development of prostate cancer. It remains controversial whether non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of prostate cancer. Here, we investigate how a previously reported inverse association between NSAID use and the risk of aggressive prostate cancer is modulated by variants in several inflammatory genes. We found that NSAIDs may have differential effects on prostate cancer development, depending on one's genetic makeup. Further study of these inflammatory pathways may clarify the mechanisms through which NSAIDs impact prostate cancer risk.

Indexed as

aspiringenetic variationnon-steroidal anti-inflammatory agentsprostatic neoplasmssingle nucleotide polymorphism

Identifiers

PMID24023525
PMCPMC3766748
OpenAlexW2033994501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.