ArticleProceedings of the National Academy of Sciences of the United States of America2013
Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution dwarf alleles in rice and barley.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45 citing papers in PubMed.
- Parallel evolution of salinity tolerance inScience advances · 2025Article
- Allelic variations in GA20ox3 regulate fruit length and seed germination timing for high-altitude adaptation in Arabidopsis thaliana.Nature communications · 2025Article
- A Genome-Wide Association Screen for Genes Affecting Leaf Trichome Development and Epidermal Metal Accumulation in Arabidopsis.Plant, cell & environment · 2025Article
- Green revolution gene drives adaptation of Arabidopsis to the extremely high altitude.Science China. Life sciences · 2025Article
- RNA-Seq Transcriptomics and iTRAQ Proteomics Analysis Reveal the Dwarfing Mechanism of Blue Fescue (Plants (Basel, Switzerland) · 2024Article
- Exploring Novel Genomic Loci and Candidate Genes Associated with Plant Height in Bulgarian Bread Wheat via Multi-Model GWAS.Plants (Basel, Switzerland) · 2024Article
- Genetic architecture and genomic prediction of plant height-related traits in chrysanthemum.Horticulture research · 2024Article
- Identification of growth regulators using cross-species network analysis in plants.Plant physiology · 2022Article
- Experimentally heat-induced transposition increases drought tolerance in Arabidopsis thaliana.The New phytologist · 2022Article
- Genome-wide association mapping within a localPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Genetics as a key to improving crop photosynthesis.Journal of experimental botany · 2022Article
- Article
- Adaptive divergence in shoot gravitropism creates hybrid sterility in an Australian wildflower.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- MYB transcription factors drive evolutionary innovations in Arabidopsis fruit trichome patterning.The Plant cell · 2021Article
- The population genomics of adaptive loss of function.Heredity · 2021Review
- AraPheno and the AraGWAS Catalog 2020: a major database update including RNA-Seq and knockout mutation data for Arabidopsis thaliana.Nucleic acids research · 2020Article
- Large-effect flowering time mutations reveal conditionally adaptive paths through fitness landscapes inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- The complex genetic architecture of shoot growth natural variation in Arabidopsis thaliana.PLoS genetics · 2019Article
- Evidence for novel epigenetic marks within plants.AIMS genetics · 2019Article
- Drought adaptation ineLife · 2018Article
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7 authors.
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Abstract
Understanding the genetic bases of natural variation for developmental and stress-related traits is a major goal of current plant biology. Variation in plant hormone levels and signaling might underlie such phenotypic variation occurring even within the same species. Here we report the genetic and molecular basis of semidwarf individuals found in natural Arabidopsis thaliana populations. Allelism tests demonstrate that independent loss-of-function mutations at GA locus 5 (GA5), which encodes gibberellin 20-oxidase 1 (GA20ox1) involved in the last steps of gibberellin biosynthesis, are found in different populations from southern, western, and northern Europe; central Asia; and Japan. Sequencing of GA5 identified 21 different loss-of-function alleles causing semidwarfness without any obvious general tradeoff affecting plant performance traits. GA5 shows signatures of purifying selection, whereas GA5 loss-of-function alleles can also exhibit patterns of positive selection in specific populations as shown by Fay and Wu's H statistics. These results suggest that antagonistic pleiotropy might underlie the occurrence of GA5 loss-of-function mutations in nature. Furthermore, because GA5 is the ortholog of rice SD1 and barley Sdw1/Denso green revolution genes, this study illustrates the occurrence of conserved adaptive evolution between wild A.thaliana and domesticated plants.
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