ArticleReproductive sciences (Thousand Oaks, Calif.)2014
Metyrapone blocks maternal food restriction-induced changes in female rat offspring lung development.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Sex-specific placental adaptations associated with fetal growth restriction: a review.Journal of animal science · 2026Review
- Effect of electro-acupuncture at ST 36 on maternal food restriction-induced lung phenotype in rat offspring.Pediatric pulmonology · 2021Article
- Maternal food restriction-induced intrauterine growth restriction in a rat model leads to sex-specific adipogenic programming.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Article
- Role of miR-29 in mediating offspring lung phenotype in a rodent model of intrauterine growth restriction.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Precocious glucocorticoid exposure reduces skeletal muscle satellite cells in the fetal rat.The Journal of endocrinology · 2017Article
- Postnatal treatment with metyrapone attenuates the effects of diet-induced obesity in female rats exposed to early-life stress.American journal of physiology. Endocrinology and metabolism · 2017Article
- Bone marrow mesenchymal stem cells of the intrauterine growth-restricted rat offspring exhibit enhanced adipogenic phenotype.International journal of obesity (2005) · 2016Article
- Long-term effects of maternal undernutrition on offspring carotid artery remodeling: role of miR-29c.Journal of developmental origins of health and disease · 2015Article
- Metyrapone alleviates deleterious effects of maternal food restriction on lung development and growth of rat offspring.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Maternal food restriction (MFR) during pregnancy affects pulmonary surfactant production in the intrauterine growth-restricted (IUGR) offspring through unknown mechanisms. Since pulmonary surfactant production is regulated by maternal and fetal corticosteroid levels, both known to be increased in IUGR pregnancies, we hypothesized that metyrapone (MTP), a glucocorticoid synthesis inhibitor, would block the effects of MFR on surfactant production in the offspring. Three groups of pregnant rat dams were used (1) control dams fed ad libitum; (2) MFR (50% reduction in calories) from days 10 to 22 of gestation; and (3) MFR + MTP in drinking water (0.5 mg/mL), days 11 to 22 of gestation. At 5 months, the MFR offspring weighed significantly more, had reduced alveolar number, increased septal thickness, and decreased surfactant protein and phospholipid synthesis. These MFR-induced effects were normalized by the antiglucocorticoid MTP, suggesting that the stress of MFR causes hypercorticoidism, altering lung structure and function in adulthood.
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Registered trials
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