Evidence map›Paper›PMID 24022896›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2014

Electrostatic control of structure in self-assembled membranes.

Ronit Bitton, Lesley W Chow, R Helen Zha, Yuri S Velichko, E Thomas Pashuck, Samuel I Stupp

Abstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Creating biomaterials with spatially organized functionality.Experimental biology and medicine (Maywood, N.J.) · 2016
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ronit BittonInstitute for BioNanotechnology in Medicine, Northwestern University, Chicago, IL, 60611, USA.
Lesley W Chow
R Helen Zha
Yuri S Velichko
E Thomas Pashuck
Samuel I Stupp

Funding

Regenerative Scaffold Technologies for CNS and DiabetesR01EB003806 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI STUPP, SAMUEL I · 2004 to 2015
$10.7M
NIBIB NIH HHS 5R01EB003806-05NIBIB NIH HHS R01 EB003806
6 · The paper itself

Abstract

Self-assembling peptide amphiphiles (PAs) can form hierarchically ordered membranes when brought in contact with aqueous polyelectrolytes of the opposite charge by rapidly creating a diffusion barrier composed of filamentous nanostructures parallel to the plane of the incipient membrane. Following this event, osmotic forces and charge complexation template nanofiber growth perpendicular to the plane of the membrane in a dynamic self-assembly process. In this work, we show that this hierarchical structure requires massive interfacial aggregation of PA molecules, suggesting the importance of rapid diffusion barrier formation. Strong PA aggregation is induced here through the use of heparin-binding PAs with heparin and also with polyelectrolytes of varying charge density. Small angle X-ray scattering shows that in the case of weak PA-polyelectrolyte interaction, membranes formed display a cubic phase ordering on the nanoscale that likely results from clusters of PA nanostructures surrounded by polyelectrolyte chains.

Indexed as

Membranes, ArtificialStatic ElectricityAcrylic ResinsAlginatesAntimicrobial Cationic PeptidesBlood ProteinsCarrageenanCarrier ProteinsGlucuronic AcidHexuronic AcidsHyaluronic AcidMicroscopy, Electron, ScanningNanostructuresPeptidesScattering, Small AngleSurface-Active AgentsAcrylic ResinsAlginatesAntimicrobial Cationic PeptidesAZU1 protein, humanBlood Proteinscarbopol 940CarrageenanCarrier ProteinsGlucuronic AcidHexuronic AcidsHyaluronic AcidMembranes, ArtificialPeptidesSurface-Active Agentsordered membranespeptide amphiphilespolyelectrolyte-supramolecular polymer complexSAXSself-assembly

Identifiers

PMID24022896
PMCPMC4096135

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.