ArticleInternational urology and nephrology2014
Apparent diffusion coefficient value as a biomarker reflecting morphological and biological features of prostate cancer.
Article in International urology and nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Possible Role of Diffusion-Weighted Imaging in Prediction of Prostate Cancer Grade Group Upgrading: Insights from Biopsy to Radical Prostatectomy.Medicina (Kaunas, Lithuania) · 2026Article
- Predicting bone metastasis and high-grade Gleason scores in prostate cancer: a retrospective study integrating clinical features and magnetic resonance imaging radiomics.Translational andrology and urology · 2025Article
- Diffusion-weighted MRI of advanced gastric cancer: correlations of the apparent diffusion coefficient with Borrmann classification, proliferation and aggressiveness.Abdominal radiology (New York) · 2025Article
- The Multipurpose Usage of Diffusion-Weighted MRI in Rectal Cancer.Medicina (Kaunas, Lithuania) · 2023Article
- Quantification of Multi-Parametric Magnetic Resonance Imaging Based on Radiomics Analysis for Differentiation of Benign and Malignant Lesions of Prostate.Journal of biomedical physics & engineering · 2023Article
- Prostate and metastasis diffusion volume based on apparent diffusion coefficient as a prognostic factor in Hormone-naïve prostate Cancer.Clinical & experimental metastasis · 2023Article
- DWI and IVIM are predictors of Ki67 proliferation index: direct comparison of MRI images and pathological slices in a murine model of rhabdomyosarcoma.European radiology · 2020Article
- Predicting side-specific prostate cancer extracapsular extension: a simple decision rule of PSA, biopsy, and MRI parameters.International urology and nephrology · 2019Article
- Potentials and challenges of diffusion-weighted magnetic resonance imaging in radiotherapy.Clinical and translational radiation oncology · 2018Review
- A negative multiparametric magnetic resonance imaging finding does not guarantee the absence of significant cancer among biopsy-proven prostate cancer patients: a real-life clinical experience.International urology and nephrology · 2018Article
- Giant Cell Tumors of the Bone: Changes in Image Features after Denosumab Administration.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2018Article
- Could IVIM and ADC help in predicting the KRAS status in patients with rectal cancer?European radiology · 2018Article
- Associations between apparent diffusion coefficient (ADC) and KI 67 in different tumors: a meta-analysis. Part 2: ADCOncotarget · 2018Article
- Primary and metastatic ovarian cancer: Characterization by 3.0T diffusion-weighted MRI.European radiology · 2017Article
- The expanding landscape of diffusion-weighted MRI in prostate cancer.Abdominal radiology (New York) · 2016Review
- Automated prostate cancer detection via comprehensive multi-parametric magnetic resonance imaging texture feature models.BMC medical imaging · 2015Article
- Diffusion-weighted MRI as a potential imaging biomarker reflecting the metastatic potential of upper urinary tract cancer.The British journal of radiology · 2014Article
- Apparent Diffusion Coefficient (ADC) value: a potential imaging biomarker that reflects the biological features of rectal cancer.PloS one · 2014Article
- Article
- Multiparametric MRI in the Detection of Clinically Significant Prostate Cancer.Korean journal of radiologyReview
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17 authors.
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Abstract
purposeTo assess whether there is an association between the apparent diffusion coefficient (ADC) value and the pathological characteristics of prostate cancer.
methodsThe study cohort consisted of 29 consecutive patients with prostate cancer treated with radical prostatectomy. All patients underwent diffusion-weighted MRI before the prostate biopsy. In 42 tumor foci, the associations of the ADC values with the clinicopathological characteristics and Ki-67 labeling index (LI) were analyzed.
resultsHigh-grade cancers (Gleason score [GS] ≥ 4 + 3), larger cancers (maximum diameter (MD) ≥ 16 mm), and highly proliferating cancers (Ki-67 LI ≥ 4.43 %) had significantly lower ADC values, respectively (P < .001, P = .008, and P = .044, respectively). There was no significant difference in ADC value according to age, prostate-specific antigen, presence of extra-prostatic extension, and intra-tumoral stroma proportion. Multivariate analysis showed that GS, Ki-67 LI, and MD had independent and significant correlations with ADC value (P < .001, P = .006, and P = .002, respectively). Low ADC tumors (<0.52 × 10(-3) mm(2)/s) are likely to be high-grade cancer foci compared with high ADC tumors (relative risk: 65.2). The sensitivity and specificity of the ADC value to predict high-grade cancer foci are 81.8 and 93.5 %, respectively.
conclusionsA low ADC value reflects the morphological and biological features of prostate cancer. Analyzing the ADC value may make it possible to more precisely predict the cancer aggressiveness of each focus before treatment.
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