ArticleJournal of autism and developmental disorders2013
Brief Report: Antibodies Reacting to Brain Tissue in Basque Spanish Children with Autism Spectrum Disorder and Their Mothers.
Article in Journal of autism and developmental disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Maternal Thyroid Dysfunction, and Child Autism Spectrum Disorder.Endocrinology and metabolism (Seoul, Korea) · 2022Review
- Maternal Immune Dysregulation and Autism-Understanding the Role of Cytokines, Chemokines and Autoantibodies.Frontiers in psychiatry · 2022Review
- Autoantibody-associated psychiatric syndromes in children: link to adult psychiatry.Journal of neural transmission (Vienna, Austria : 1996) · 2021Review
- Immune regulation of neurodevelopment at the mother-foetus interface: the case of autism.Clinical & translational immunology · 2020Review
- T lymphocytes and cytotoxic astrocyte blebs correlate across autism brains.Annals of neurology · 2019Article
- Prenatal Stress and Maternal Immune Dysregulation in Autism Spectrum Disorders: Potential Points for Intervention.Current pharmaceutical design · 2019Review
- Maternal Antibody and ASD: Clinical Data and Animal Models.Frontiers in immunology · 2019Review
- Immune Abnormalities in Autism Spectrum Disorder-Could They Hold Promise for Causative Treatment?Molecular neurobiology · 2018Review
- Immune Dysfunction and Autoimmunity as Pathological Mechanisms in Autism Spectrum Disorders.Frontiers in cellular neuroscience · 2018Review
- Beyond infection - Maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders.Experimental neurology · 2018Review
- Anti-brain antibodies are associated with more severe cognitive and behavioral profiles in Italian children with Autism Spectrum Disorder.Brain, behavior, and immunity · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Previous investigations found that a subset of children with autism spectrum disorder (ASD) in California possessed plasma autoantibodies that reacted intensely with brain interneurons or other neural profiles. Moreover, for several cohorts of American women, maternal autoantibody reactivity to specific fetal brain proteins was highly specific to mothers of children with ASD. We sought to determine whether children and their mothers from a regionally specific cohort from the Basque Country of Spain demonstrated similar reactivity. Some children's plasma reacted to interneurons, beaded axons or other neural profiles with no difference in the occurrence of these antibodies in children with or without ASD. Findings on the maternal antibodies confirmed previous research; plasma reactivity to fetal brain a combination of proteins at 37 and 73 kDa or 39 and 73 kDa was found exclusively in mothers of children with ASD.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.