ArticleArthritis and rheumatism2013
Prevalence of the fibromyalgia phenotype in patients with spine pain presenting to a tertiary care pain clinic and the potential treatment implications.
Article in Arthritis and rheumatism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- Mixed pain phenotypes in musculoskeletal disorders: mechanisms and management.Nature reviews. Rheumatology · 2026Review
- Decoding pain in axial spondyloarthritis: Mechanisms, management, and future directions.Best practice & research. Clinical rheumatology · 2026Review
- Randomized controlled trial of medical assistant-coached behavioral intervention for chronic pain.Regional anesthesia and pain medicine · 2026Article
- Comparing physical activity practice, pain and psychological characteristics in individuals with fibromyalgia and individuals with low back pain.Chiropractic & manual therapies · 2026Article
- At-Home Morning Bright Light Treatment for Chronic Nociplastic Pain: Protocol for a Randomized Clinical Trial.JMIR research protocols · 2025Article
- Unintended Prolonged Opioid Use: Protocol for a Case-Controlled Trial.JMIR research protocols · 2025Article
- The number of central nervous system-driven symptoms predicts subsequent chronic primary pain: evidence from UK Biobank.British journal of anaesthesia · 2025Article
- The Association Between the Patient Self-Report Survey for the Assessment of Fibromyalgia with Pain Sensitivity and Psychological Factors in Individuals with Musculoskeletal Pain.Journal of pain research · 2023Article
- Correlation of Fibromyalgia Survey Questionnaire and Quantitative Sensory Testing Among Patients With Active Rheumatoid Arthritis.The Journal of rheumatology · 2022Article
- Insulin Resistance is Associated with Central Pain in Patients with Fibromyalgia.Pain physician · 2021Observational
- Medical cannabis for the treatment of fibromyalgia syndrome: a retrospective, open-label case series.Journal of cannabis research · 2021Article
- Diagnostic Accuracy of ACR 2010 Preliminary Diagnostic Criteria in the Diagnosis of Fibromyalgia Among Chronic Backache Patients.Indian journal of orthopaedics · 2020Article
- A Subgroup of Chronic Low Back Pain Patients With Central Sensitization.The Clinical journal of pain · 2019Article
- Medial branch radiofrequency ablation outcomes in patients with centralized pain.Regional anesthesia and pain medicine · 2019Article
- Posttraumatic Stress Symptoms Mediate the Effects of Trauma Exposure on Clinical Indicators of Central Sensitization in Patients With Chronic Pain.The Clinical journal of pain · 2019Article
- Primary and Secondary Fibromyalgia Are The Same: The Universality of Polysymptomatic Distress.The Journal of rheumatology · 2019Article
- Affect and Low Back Pain: More to Consider Than the Influence of Negative Affect Alone.The Clinical journal of pain · 2016Article
- Fibromyalgia and Chronic Pain Syndromes: A White Paper Detailing Current Challenges in the Field.The Clinical journal of pain · 2016Article
- Article
- Deconstructing chronic low back pain in the older adult--Step by step evidence and expert-based recommendations for evaluation and treatment part III: Fibromyalgia syndrome.Pain medicine (Malden, Mass.) · 2015Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveInjections for spinal pain have high failure rates, emphasizing the importance of patient selection. It is possible that detecting the presence of a fibromyalgia (FM)-like phenotype could aid in prediction, because in these individuals a peripheral injection would not address pain due to alterations in central neurotransmission. We undertook this study to test the hypothesis that patients who have spine pain meeting survey criteria for FM would be phenotypically distinct from those who do not.
methodsWe studied 548 patients diagnosed as having primary spine pain. All patients completed validated self-report questionnaires, including the Brief Pain Inventory, the PainDETECT questionnaire, the Hospital Anxiety and Depression Scale, measures of physical function, and the FM criteria and severity scales.
resultsForty-two percent of the patients were FM positive according to the FM criteria and severity scales. Compared with FM-negative patients, FM-positive patients were more likely to be younger, unemployed, and receiving compensation for pain and to have greater pain severity and pain interference and more neuropathic pain descriptors as well as higher levels of depression and anxiety and a lower level of physical function (P < 0.002 for each comparison). Female sex, neuropathic pain, pain interference, and anxiety were independently predictive of FM status in a multivariate analysis (P < 0.01 for all variables). Receiver operating characteristic curve analysis showed a strength of association of 0.80 as measured by the cross-validated C statistic.
conclusionUsing the FM criteria and severity scales, we demonstrated profound phenotypic differences in a population of patients with spine pain. Although centralized pain cannot be confirmed with a self-report instrument alone, the pathophysiology of FM may help explain a portion of the variability of responses to spine interventions.
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