ArticleDiabetologia2013
Is there evidence for post-translational modification of beta cell autoantigens in the aetiology and pathogenesis of type 1 diabetes?
Article in Diabetologia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Current status of PTMs structural databases: applications, limitations and prospects.Amino acids · 2022Review
- Molecular mechanisms in autoimmune type 1 diabetes: a critical review.Clinical reviews in allergy & immunology · 2014Review
- Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Størling and colleagues hypothesise in this issue (Diabetologia DOI: 10.1007/s00125-013-3045-3 ) that post-translational modification (PTM) of autoantigens might create tissue-specific neo-epitopes that could trigger type 1 diabetes. Data on PTM of islet autoantigens are scarce and readers should not believe that the PTM hypothesis is supported by strong experimental evidence. The proposed genetic factors are many but their possible contribution is conjectural. There is a lack of a rational approach to test the PTM hypothesis at the different stages of type 1 diabetes. Research that carefully addresses each stage of the type 1 diabetes disease process is warranted to advance our understanding of autoimmune (type 1) diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.