SynthesisTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
Effect of GSTM1 null genotype on risk of childhood acute leukemia: a meta-analysis.
Synthesis in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association Between the Individual and Combined Effects of theFrontiers in genetics · 2022Pooled it
- Individual and combined effects of theFrontiers in genetics · 2022Pooled it
- The IKAROS Transcription Factor Gene IKZF1 as a Critical Regulator in the Pathogenesis of Childhood Acute Lymphoblastic Leukemia: Insights from a Bangladeshi Population.Indian journal of clinical biochemistry : IJCB · 2025Article
- Association of GSTM1 Deletion With Progression of CKD in Children: Findings From the Chronic Kidney Disease in Children (CKiD) Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Observational
- FHIT promoter DNA methylation and expression analysis in childhood acute lymphoblastic leukemia.Oncology letters · 2017Article
- IKZF1 gene polymorphisms increased the risk of childhood acute lymphoblastic leukemia in an Iranian population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Association between Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphisms and Susceptibility to Childhood Acute Lymphoblastic Leukemia in an Iranian Population.International journal of hematology-oncology and stem cell research · 2016Article
- Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric OncologyArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutathione S-transferases are important enzymes in the detoxification of a wide range of reactive oxygen species. Recently, there have been a number of studies on the association between Glutathione S-transferase M1 (GSTM1) null genotype and childhood acute leukemia in Chinese, but the results of previous reports are inconsistent. Thus, we performed a meta-analysis to clarify the effect of GSTM1 null genotype on childhood acute leukemia risk. PubMed, Embase, and Wanfang databases were searched to identify case–control studies investigating the association between GSTM1 null genotype and risk of childhood acute leukemia. Between-study heterogeneity was assessed using the I2 statistic method. Odds ratios (OR) with corresponding 95% confidence intervals (95% CI) were pooled to assess the association. Seven case–control studies were finally included in the meta-analysis. There was no between-study heterogeneity among those seven studies (I2 = 0%). Overall, the GSTM1 null genotype was significantly associated with increased risk of childhood acute leukemia in Chinese (fixed effect OR = 2.49; 95% CI, 1.84–3.37; P < 0.001). The cumulative meta-analyses showed a trend of more obvious association between GSTM1 null genotype and risk of childhood acute leukemia in Chinese as data accumulated by year. Sensitivity analysis by omitting single study in turns also did not materially alter the pooled ORs. Therefore, the GSTM1 null genotype is significantly associated with increased risk of childhood acute leukemia in Chinese.
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