ArticleHeredity2014
A genome-wide scan study identifies a single nucleotide substitution in ASIP associated with white versus non-white coat-colour variation in sheep (Ovis aries).
Article in Heredity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 64 citations in OpenAlex.
- Article
- Assessment of a Reduced SNP Panel Targeting Prolificacy and Coat Color Genes in Brazilian Sheep Breeds.Animals : an open access journal from MDPI · 2026Article
- Causal variants in animal genomes: approaches to identification, phenotypic impact, and implications for selective breeding.BMC genomics · 2026Review
- Integrative Methylome and Transcriptome Analysis Reveals Epigenetic Regulation of Pigmentation in Oujiang Color Common Carp.International journal of molecular sciences · 2025Article
- Mouflon and Domestic Sheep Phylogeny: Ancestry, Domestication, and Evolutionary Dynamics.Life (Basel, Switzerland) · 2025Review
- Selection signatures of wool color in Gangba sheep revealed by genome-wide SNP discovery.BMC genomics · 2024Article
- Selection signatures and landscape genomics analysis to reveal climate adaptation of goat breeds.BMC genomics · 2024Article
- Genetic structure and selective sweeps in Kirghiz sheep using SNP50K bead chip.Frontiers in genetics · 2024Article
- Genome-wide association study for polledness, horn shape, and wool traits in Original Valachian sheep.Archives animal breeding · 2024Article
- Whole Genome Resequencing Reveals Selection Signals Related to Wool Color in Sheep.Animals : an open access journal from MDPI · 2023Article
- The Hoof Color of Australian White Sheep Is Associated with Genetic Variation of theAnimals : an open access journal from MDPI · 2023Article
- Genome-wide association study revealed the genomic regions associated with skin pigmentation in an Ogye x White Leghorn F2 chicken population.Poultry science · 2023Article
- Genome-Wide Association Analysis of Muscle pH in Texel Sheep × Altay Sheep FAnimals : an open access journal from MDPI · 2023Article
- Genetic diversity, population structure, and selective signature of sheep in the northeastern Tarim Basin.Frontiers in genetics · 2023Article
- A genome-wide association study of coat color in Chinese Rex rabbits.Frontiers in veterinary science · 2023Article
- Whole-genome resequencing reveals molecular imprints of anthropogenic and natural selection in wild and domesticated sheep.Zoological research · 2022Article
- Genetics of the phenotypic evolution in sheep: a molecular look at diversity-driving genes.Genetics, selection, evolution : GSE · 2022Review
- Trait Analysis in Domestic Rabbits (Animals : an open access journal from MDPI · 2022Article
- Analysis on the desert adaptability of indigenous sheep in the southern edge of Taklimakan Desert.Scientific reports · 2022Article
- Genomic Scan for Selection Signature Reveals Fat Deposition in Chinese Indigenous Sheep with Extreme Tail Types.Animals : an open access journal from MDPI · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In sheep, coat colour (and pattern) is one of the important traits of great biological, economic and social importance. However, the genetics of sheep coat colour has not yet been fully clarified. We conducted a genome-wide association study of sheep coat colours by genotyping 47 303 single-nucleotide polymorphisms (SNPs) in the Finnsheep population in Finland. We identified 35 SNPs associated with all the coat colours studied, which cover genomic regions encompassing three known pigmentation genes (TYRP1, ASIP and MITF) in sheep. Eighteen of these associations were confirmed in further tests between white versus non-white individuals, but none of the 35 associations were significant in the analysis of only non-white colours. Across the tests, the s66432.1 in ASIP showed significant association (P=4.2 × 10(-11) for all the colours; P=2.3 × 10(-11) for white versus non-white colours) with the variation in coat colours and strong linkage disequilibrium with other significant variants surrounding the ASIP gene. The signals detected around the ASIP gene were explained by differences in white versus non-white alleles. Further, a genome scan for selection for white coat pigmentation identified a strong and striking selection signal spanning ASIP. Our study identified the main candidate gene for the coat colour variation between white and non-white as ASIP, an autosomal gene that has been directly implicated in the pathway regulating melanogenesis. Together with ASIP, the two other newly identified genes (TYRP1 and MITF) in the Finnsheep, bordering associated SNPs, represent a new resource for enriching sheep coat-colour genetics and breeding.
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