ReviewCurrent allergy and asthma reports2013
Cellular immune response in young children accounts for recurrent acute otitis media.
Review in Current allergy and asthma reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Effects of the Traditional Mediterranean Diet in Patients with Otitis Media with Effusion.Nutrients · 2021Trial
- Niche- and Gender-Dependent Immune Reactions in Relation to the Microbiota Profile in Pediatric Patients with Otitis Media with Effusion.Infection and immunity · 2020Article
- Immunologic dysfunction contributes to the otitis prone condition.The Journal of infection · 2020Review
- Immune Network Modeling Predicts Specific Nasopharyngeal and Peripheral Immune Dysregulation in Otitis-Prone Children.Frontiers in immunology · 2020Article
- Cellular Immune Response against NontypeableInfection and immunity · 2019Article
- Subversion of host immune responses by otopathogens during otitis media.Journal of leukocyte biology · 2019Review
- Cellular content plays a crucial role in Non-typeable Haemophilus influenzae infection of preinflamed Junbo mouse middle ear.Cellular microbiology · 2019Article
- The Influence of Age on the Relationship Between Allergic Rhinitis and Otitis Media.Current allergy and asthma reports · 2018Review
- Evidence of functional cell-mediated immune responses to nontypeable Haemophilus influenzae in otitis-prone children.PloS one · 2018Article
- Noninvasive in vivo optical coherence tomography tracking of chronic otitis media in pediatric subjects after surgical intervention.Journal of biomedical optics · 2017Article
- Otitis-Prone Children Produce Functional Antibodies to Pneumolysin and Pneumococcal Polysaccharides.Clinical and vaccine immunology : CVI · 2017Article
- Differences in innate immune response gene regulation in the middle ear of children who are otitis prone and in those not otitis prone.American journal of rhinology & allergy · 2016Article
- Immunization with Protein D from Non-TypeableJundishapur journal of microbiology · 2016Article
- Ten-Year Study of the Stringently Defined Otitis-prone Child in Rochester, NY.The Pediatric infectious disease journal · 2016Review
- Innate Immunity: Orchestrating Inflammation and Resolution of Otitis Media.Current allergy and asthma reports · 2016Review
- Familial and microbiological contribution to the otitis-prone condition.International journal of pediatric otorhinolaryngology · 2015Article
- Humoral immune responses to Streptococcus pneumoniae in the setting of HIV-1 infection.Vaccine · 2015Review
- Synchrony in serum antibody response to conserved proteins of Streptococcus pneumoniae in young children.Human vaccines & immunotherapeutics · 2015Article
- What does tympanostomy tube placement in children teach us about the association between atopic conditions and otitis media?Current allergy and asthma reports · 2014Review
- Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Acute otitis media (AOM) is a common disease in young children. Streptococcus pneumoniae (Spn) and Haemophilus influenzae (NTHi) are the two most common pathogens that cause AOM. Over the past 5 years, our group has been studying the immunologic profile of children that experience repeated AOM infections despite tympanocentesis drainage of middle ear fluid and individualized antibiotic treatment; we call these children stringently-defined otitis prone(sOP). Although protection against AOM is primarily mediated by ototpathogen-specific antibody, our recent studies suggest that suboptimal memory B and T cell responses and an immaturity in antigen-presenting cells may play a significant role in the propensity to recurrent AOM infections. This review focuses on the studies performed to define immunologic dysfunction in sOP children.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.