Evidence map›Paper›PMID 24022301›Full record

ArticleEuropean journal of human genetics : EJHG2014

Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort.

Jessica Becker, Darina Czamara, Tom S Scerri, Franck Ramus, Valéria Csépe, Joel B Talcott, John Stein, Andrew Morris, Kerstin U Ludwig, Per Hoffmann and 31 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of human genetics : EJHG, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
9.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.

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  12. Development of Dyslexia: The Delayed Neural Commitment Framework.Frontiers in behavioral neuroscience · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors at 20 institutions in 10 countries.

Jessica Becker1] Institute of Human Genetics, University of Bonn, Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
Darina Czamara1] Max Planck Institute of Psychiatry, Munich, Germany [2] Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Tom S Scerri1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK [2] Walter and Eliza Hall Institute for Medical Research, Melbourne, Victoria, Australia.
Franck RamusLaboratoire de Sciences Cognitives et Psycholinguistique, Ecole Normale Supérieure, CNRS, EHESS, Paris, France.
Valéria CsépeInstitute of Cognitive Neuroscience and Psychology, Research Centre of Natural Sciences of the Hungarian Academy of Sciences Budapest, Budapest, Hungary.
Joel B TalcottSchool of Life and Health Sciences, Aston University, Birmingham, UK.
John SteinDepartment of Physiology, University of Oxford, Oxford, UK.
Andrew MorrisWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Kerstin U Ludwig1] Institute of Human Genetics, University of Bonn, Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
Per Hoffmann1] Institute of Human Genetics, University of Bonn, Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany [3] Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland.ORCID 000000026573983X
Ferenc HonbolygóInstitute of Cognitive Neuroscience and Psychology, Research Centre of Natural Sciences of the Hungarian Academy of Sciences Budapest, Budapest, Hungary.
Dénes TóthInstitute of Cognitive Neuroscience and Psychology, Research Centre of Natural Sciences of the Hungarian Academy of Sciences Budapest, Budapest, Hungary.
Fabien Fauchereau1] Human Genetics and Cognitive Functions, CNRS URA 2182, Institut Pasteur, Paris, France [2] Sorbonne Paris Cité, Université Paris Diderot, Paris, France.
Caroline BogliottiLaboratoire de Sciences Cognitives et Psycholinguistique, Ecole Normale Supérieure, CNRS, EHESS, Paris, France.
Stéphanie Iannuzzi1] Unité de Neurologie Pédiatrique, Hôpital des Enfants, Toulouse, France [2] Inserm U825, Hôpital Purpan, Toulouse, France [3] Centre de Référence sur les Troubles des Apprentissages, Hôpital Bicêtre, Paris, France.
Yves Chaix1] Unité de Neurologie Pédiatrique, Hôpital des Enfants, Toulouse, France [2] Inserm U825, Hôpital Purpan, Toulouse, France.
Sylviane Valdois1] Laboratoire de Psychologie et NeuroCognition UMR 5105 CNRS, Université Pierre Mendès France, Grenoble, France [2] Centre référent pour le diagnostic des troubles du langage et des apprentissages, Département de pédiatrie, CHU Nord, Grenoble, France.
Catherine BillardCentre de Référence sur les Troubles des Apprentissages, Hôpital Bicêtre, Paris, France.
Florence GeorgeCentre de Référence des Troubles d'apprentissage, CHU Timone, Marseille, France.
Isabelle Soares-Boucaud1] Centre de Référence pour les Troubles des Apprentissages, Hospices Civils de Lyon, Hôpital E Herriot, Lyon, France [2] Centre Hospitalier Le Vinatier, Bron, France.
Christophe-Loïc GérardService de Psychopathologie de l'enfant et de l'adolescent, Hôpital Robert Debré, APHP, Paris, France.
Sanne van der MarkDepartment of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland.
Enrico Schulz1] TUM-Neuroimaging Center, Technische Universität München, Munich, Germany [2] Department of Neurology, Technische Universität München, Munich, Germany.
Anniek VaessenDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience & Maastricht Brain Imaging Institute (M-BIC), Maastricht University, Maastricht, The Netherlands.
Urs Maurer1] Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland [2] Department of Psychology, University of Zurich, Zurich, Switzerland [3] Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
Kaisa LohvansuuFinnish Center of Excellence in Learning and Motivation Research, Department of Psychology, University of Jyväskylä, Jyväskylä, Finland.
Heikki LyytinenFinnish Center of Excellence in Learning and Motivation Research, Department of Psychology, University of Jyväskylä, Jyväskylä, Finland.
Marco ZucchelliDepartment of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Daniel Brandeis1] Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland [2] Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland [3] Zurich Center for Integrative Human Physiology (ZIHP), Zurich, Switzerland [4] Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
Leo BlomertDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience & Maastricht Brain Imaging Institute (M-BIC), Maastricht University, Maastricht, The Netherlands.
Paavo H T LeppänenFinnish Center of Excellence in Learning and Motivation Research, Department of Psychology, University of Jyväskylä, Jyväskylä, Finland.
Jennifer BruderDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.
Anthony P MonacoWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Bertram Müller-Myhsok1] Max Planck Institute of Psychiatry, Munich, Germany [2] Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Juha Kere1] Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden [2] Molecular Medicine Program, Biomedicum, University of Helsinki and Folkhälsan Institute of Genetics, Helsinki, Finland.
Karin LanderlDepartment of Psychology, University of Graz, Graz, Austria.
Markus M Nöthen1] Institute of Human Genetics, University of Bonn, Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
Gerd Schulte-KörneDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.
Silvia Paracchini1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK [2] School of Medicine, University of St Andrews, St Andrews, UK.
Myriam Peyrard-JanvidDepartment of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Johannes SchumacherInstitute of Human Genetics, University of Bonn, Bonn, Germany.
University of Bonn · DECentre for Human Genetics · GBCentre National de la Recherche Scientifique · FRInstitute of Cognitive Neuroscience and Psychology · HUKarolinska Institutet · SEMotiva (Finland) · FIUniversity of Zurich · CHInserm · FRLudwig-Maximilians-Universität München · DEMaastricht University · NLMunich Cluster for Systems Neurology · DEAssistance Publique – Hôpitaux de Paris · FRAston University · GBBicêtre Hospital · FRDélégation Provence et Corse · FRHospices Civils de Lyon · FRTechnical University of Munich · DEUniversité Pierre Mendès France · FRUniversity of Graz · ATUniversity of Oxford · GB

Funding

Wellcome Trust 090532
6 · The paper itself

Abstract

Dyslexia is one of the most common childhood disorders with a prevalence of around 5-10% in school-age children. Although an important genetic component is known to have a role in the aetiology of dyslexia, we are far from understanding the molecular mechanisms leading to the disorder. Several candidate genes have been implicated in dyslexia, including DYX1C1, DCDC2, KIAA0319, and the MRPL19/C2ORF3 locus, each with reports of both positive and no replications. We generated a European cross-linguistic sample of school-age children - the NeuroDys cohort - that includes more than 900 individuals with dyslexia, sampled with homogenous inclusion criteria across eight European countries, and a comparable number of controls. Here, we describe association analysis of the dyslexia candidate genes/locus in the NeuroDys cohort. We performed both case-control and quantitative association analyses of single markers and haplotypes previously reported to be dyslexia-associated. Although we observed association signals in samples from single countries, we did not find any marker or haplotype that was significantly associated with either case-control status or quantitative measurements of word-reading or spelling in the meta-analysis of all eight countries combined. Like in other neurocognitive disorders, our findings underline the need for larger sample sizes to validate possibly weak genetic effects.

Indexed as

Genetic Association StudiesGenome-Wide Association StudyCase-Control StudiesDyslexiaGenetic LociGenotypeHaplotypesHumansMeta-Analysis as TopicPhenotypePolymorphism, Single NucleotideQuantitative Trait, Heritable

Identifiers

PMID24022301
PMCPMC3992562
OpenAlexW2037089701

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.