ArticleChemical communications (Cambridge, England)2013
Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation.
Article in Chemical communications (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Toll-like Receptor Agonist Conjugation: A Chemical Perspective.Bioconjugate chemistry · 2018Review
- Cell Membrane Bioconjugation and Membrane-Derived Nanomaterials for Immunotherapy.Bioconjugate chemistry · 2018Review
- Immunogenic Cell Death Amplified by Co-localized Adjuvant Delivery for Cancer Immunotherapy.Nano letters · 2017Article
- Targeting CpG Adjuvant to Lymph Node via Dextran Conjugate Enhances Antitumor Immunotherapy.Bioconjugate chemistry · 2017Article
- Impact of dose, route, and composition on the immunogenicity of immune polyelectrolyte multilayers delivered on gold templates.Biotechnology and bioengineering · 2017Article
- Review
- Targeted Programming of the Lymph Node Environment Causes Evolution of Local and Systemic Immunity.Cellular and molecular bioengineering · 2016Article
- Biomimetic and synthetic interfaces to tune immune responses.Biointerphases · 2015Review
- Guiding principles in the design of molecular bioconjugates for vaccine applications.Bioconjugate chemistry · 2015Review
- Directing the immune system with chemical compounds.ACS chemical biology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We present a primary example of a cell surface modified with a synergistic combination of agonists to tune immune stimulation. A model cell line, Lewis Lung Carcinoma, was covalently modified with CpG-oligonucleotides and lipoteichoic acid, both Toll-like receptor (TLR) agonists. The immune-stimulating constructs provided greater stimulation of NF-κB in a model cell line and bone marrow-derived dendritic cells than the components unconjugated in solution.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.