ArticleMolecular systems biology2013
Barriers to transmission of transcriptional noise in a c-fos c-jun pathway.
Article in Molecular systems biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
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- Acryl-3,5-bis(2,4-difluorobenzylidene)-4-piperidone targeting cellular JUN proto-oncogene, AP-1 transcription factor subunit inhibits head and neck squamous cell carcinoma progression.Exploration of targeted anti-tumor therapy · 2023Article
- Allelic correlation is a marker of trade-offs between barriers to transmission of expression variability and signal responsiveness in genetic networks.Cell systems · 2022Article
- Inferring gene regulation from stochastic transcriptional variation across single cells at steady state.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Reduction in gene expression noise by targeted increase in accessibility at gene loci.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The circadian oscillator analysed at the single-transcript level.Molecular systems biology · 2021Article
- Hyper-Activation of mPFC Underlies Specific Traumatic Stress-Induced Sleep-Wake EEG Disturbances.Frontiers in neuroscience · 2020Article
- Fluorescence In Situ Imaging of Dendritic RNAs at Single-Molecule Resolution.Current protocols in neuroscience · 2019Article
- Noise in the Vertebrate Segmentation Clock Is Boosted by Time Delays but Tamed by Notch Signaling.Cell reports · 2018Article
- FISH-Flow, a protocol for the concurrent detection of mRNA and protein in single cells using fluorescence in situ hybridization and flow cytometry.Nature protocols · 2017Article
- What's Luck Got to Do with It: Single Cells, Multiple Fates, and Biological Nondeterminism.Molecular cell · 2016Review
- Single-cell differences in matrix gene expression do not predict matrix deposition.Nature communications · 2016Article
- Flow Cytometric Characterization of Antigen-Specific T Cells Based on RNA and Its Advantages in Detecting Infections and Immunological Disorders.Critical reviews in immunology · 2016Article
- Intracellular Information Processing through Encoding and Decoding of Dynamic Signaling Features.PLoS computational biology · 2015Article
- Transcription factors modulate c-Fos transcriptional bursts.Cell reports · 2014Article
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2 authors.
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Abstract
We explored how transcriptional noise propagates in gene-regulatory pathways by studying the induction of two downstream genes by transcription factors c-fos and c-jun. They are produced for a brief period following serum stimulation of cells and then activate the promoters of their target genes by binding to them as heterodimers. We found that, even though they are coordinately expressed at the population level, in individual cells the expression of c-fos and c-jun is noisy and uncorrelated with each other. The expression of the downstream genes is also noisy, but there is little or no effect of the noise in the upstream genes on the expression of the downstream genes. The noise is not transmitted, because the number of heterodimers present in single cells is relatively invariant, and the induction of downstream genes is insensitive to the number of heterodimers in individual cells. Sequestration of promoters of the downstream genes within compact chromatin is a likely cause of this insensitivity. These barriers to the propagation and amplification of noise are likely to be commonplace in higher eukaryotes.
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