SynthesisRegulatory toxicology and pharmacology : RTP2013
DDT/DDE and breast cancer: a meta-analysis.
Synthesis in Regulatory toxicology and pharmacology : RTP, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Pooled it
- Endocrine-disrupting chemicals and breast cancer: a meta-analysis.Frontiers in oncology · 2023Pooled it
- Article
- Article
- Bisphenol A and DDT disrupt adipocyte function in the mammary gland: implications for breast cancer risk and progression.Frontiers in oncology · 2025Review
- Mosquito control exposures and breast cancer risk: analysis of 1071 cases and 2096 controls from the Ghana Breast Health Study.Breast cancer research : BCR · 2023Article
- Exposure to environmental chemicals and cancer risk: epidemiological evidence from Japanese studies.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2023Review
- Article
- Epidemiology beyond its limits.Science advances · 2022Article
- Cancer Progress and Priorities: Breast Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Review
- Agrochemicals with estrogenic endocrine disrupting properties: Lessons Learned?Molecular and cellular endocrinology · 2020Review
- Exposure to Endocrine Disrupting Chemicals and Risk of Breast Cancer.International journal of molecular sciences · 2020Review
- Herbicide, fumigant, and fungicide use and breast cancer risk among farmers' wives.Environmental epidemiology (Philadelphia, Pa.) · 2020Article
- DDT exposure during pregnancy and DNA methylation alterations in female offspring in the Child Health and Development Study.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Environmental Endocrine-Disrupting Chemical Exposure: Role in Non-Communicable Diseases.Frontiers in public health · 2020Review
- Risk of breast cancer and adipose tissue concentrations of polychlorinated biphenyls and organochlorine pesticides: a hospital-based case-control study in Chinese women.Environmental science and pollution research international · 2019Article
- Urinary concentrations of environmental phenols and their associations with breast cancer incidence and mortality following breast cancer.Environment international · 2019Article
- Persistent Organic Pollutants and Breast Cancer: A Systematic Review and Critical Appraisal of the Literature.Cancers · 2019Review
- Plasma levels of dichlorodiphenyldichloroethene (DDE) and dichlorodiphenyltrichloroethane (DDT) and survival following breast cancer in the Carolina Breast Cancer Study.Environment international · 2019Article
- Statistical Methodology in Studies of Prenatal Exposure to Mixtures of Endocrine-Disrupting Chemicals: A Review of Existing Approaches and New Alternatives.Environmental health perspectives · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The biological basis for investigating dichlorodiphenyltrichloroethane (DDT) exposure and breast cancer risk stems from in vitro and animal studies indicating that DDT has estrogenic properties. The objective of this study was to update a meta-analysis from 2004 which found no association between dichlorodiphenyldichloroethylene (DDE) and breast cancer. We searched PubMed and Web of Science for studies published through June 2012 assessing DDT/DDE exposure and breast cancer. Summary Odds Ratios (ORs) with 95% confidence intervals (CIs) were calculated for the prevalence of breast cancer in the highest versus the lowest exposed groups for DDT and DDE. Difference of means of exposure for cases versus controls was analyzed for DDT and DDE. From the 500 studies screened, 46 were included in the meta-analysis. Slightly elevated, but not statistically significant summary ORs were found for DDE (1.05; 95% CI: 0.93-1.18) and DDT (1.02; 95% CI: 0.92-1.13). Lipid adjusted difference of means analysis found a significantly higher DDE concentration in cases versus controls (11.30 ng/g lipid; p=0.01). No other difference of means analysis found significant relationships. The existing information does not support the hypothesis that exposure to DDT/DDE increases the risk of breast cancer in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.