ArticleBMC genomics2013
Expansion of ruminant-specific microRNAs shapes target gene expression divergence between ruminant and non-ruminant species.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Changes in the microRNA cargo of granulosa cell-derived extracellular vesicles under oxidative stress in a bovine model.Biological research · 2026Article
- Comparative Analysis of miRNA Expression Profiles of Yak Milk-Derived Exosomes at Different Altitudes.Animals : an open access journal from MDPI · 2025Article
- Analysis of circulating-microRNA expression in lactating Holstein cows under summer heat stress.PloS one · 2020Article
- miRWoods: Enhanced precursor detection and stacked random forests for the sensitive detection of microRNAs.PLoS computational biology · 2019Article
- Growing old, yet staying young: The role of telomeres in bats' exceptional longevity.Science advances · 2018Article
- Discovery and characterization of the feline miRNAome.Scientific reports · 2017Article
- A high-quality annotated transcriptome of swine peripheral blood.BMC genomics · 2017Article
- miR-148a and miR-17-5p synergistically regulate milk TAG synthesis via PPARGC1A and PPARA in goat mammary epithelial cells.RNA biology · 2017Article
- Blood miRNomes and transcriptomes reveal novel longevity mechanisms in the long-lived bat, Myotis myotis.BMC genomics · 2016Article
- MicroRNA profiling of antler stem cells in potentiated and dormant states and their potential roles in antler regeneration.Molecular genetics and genomics : MGG · 2016Article
- Deep sequencing shows microRNA involvement in bovine mammary gland adaptation to diets supplemented with linseed oil or safflower oil.BMC genomics · 2015Article
- Genome-wide whole blood microRNAome and transcriptome analyses reveal miRNA-mRNA regulated host response to foodborne pathogen Salmonella infection in swine.Scientific reports · 2015Article
- Roles of small RNAs in the effects of nutrition on apoptosis and spermatogenesis in the adult testis.Scientific reports · 2015Article
- Annotation of the goat genome using next generation sequencing of microRNA expressed by the lactating mammary gland: comparison of three approaches.BMC genomics · 2015Article
- Potential regulatory role of microRNAs in the development of bovine gastrointestinal tract during early life.PloS one · 2014Article
- MicroRNA buffering and altered variance of gene expression in response to Salmonella infection.PloS one · 2014Article
- Characterisation and comparison of lactating mouse and bovine mammary gland miRNomes.PloS one · 2014Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUnderstanding how species-specific microRNAs (miRNAs) contribute to species-specific phenotypes is a central topic in biology. This study aimed to elucidate the role of ruminant-specific miRNAs in shaping mRNA expression divergence between ruminant and non-ruminant species.
resultsWe analyzed miRNA and mRNA transcriptomes generated by Illumina sequencing from whole blood samples of cattle and a closely related non-ruminant species, pig. We found evidence of expansion of cattle-specific miRNAs by analyzing miRNA conservation among 57 vertebrate species. The emergence of cattle-specific miRNAs was accompanied by accelerated sequence evolution at their target sites. Further, the target genes of cattle-specific miRNAs show markedly reduced expression compared to their pig and human orthologues. We found that target genes with conserved or non-conserved target sites of cattle-specific miRNAs exhibit reduced expression. One of the significantly enriched KEGG pathway terms for the target genes of the cattle-specific miRNAs is the insulin signalling pathway, raising the possibility that some of these miRNAs may modulate insulin resistance in ruminants.
conclusionsWe provide evidence of rapid miRNA-mediated regulatory evolution in the ruminant lineage. Cattle-specific miRNAs play an important role in shaping gene expression divergence between ruminant and non-ruminant species, by influencing the expression of targets genes through both conserved and cattle-specific target sites.
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