ArticleParasites & vectors2013
The predicted secretome and transmembranome of the poultry red mite Dermanyssus gallinae.
Article in Parasites & vectors, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 41 citations in OpenAlex.
- Differential gene expression and microRNA profile in corpora allata-corpora cardiaca of Aedes aegypti mosquitoes with weak juvenile hormone signalling.BMC genomics · 2024Article
- Dermanyssus gallinae: the long journey of the poultry red mite to become a vector.Parasites & vectors · 2022Review
- Transcriptomic analysis of the poultry red mite, Dermanyssus gallinae, across all stages of the lifecycle.BMC genomics · 2021Article
- A nonexhaustive overview on potential impacts of the poultry red mite (Dermanyssus gallinae) on poultry production systems.Journal of animal science · 2020Article
- De novo transcriptome sequencing and differential gene expression analysis of two parasitic human Demodex species.Parasitology research · 2019Article
- Article
- Field evaluation of poultry red mite (Dermanyssus gallinae) native and recombinant prototype vaccines.Veterinary parasitology · 2017Article
- A method to identify protein antigens of Dermanyssus gallinae for the protection of birds from poultry mites.Parasitology research · 2016Article
- De novo RNA-Seq and functional annotation of Sarcoptes scabiei canis.Parasitology research · 2016Article
- Genome-wide analysis of excretory/secretory proteins in Echinococcus multilocularis: insights into functional characteristics of the tapeworm secretome.Parasites & vectors · 2015Article
- Identification and evaluation of vaccine candidate antigens from the poultry red mite (Dermanyssus gallinae).International journal for parasitology · 2015Article
- Characterisation of Dermanyssus gallinae glutathione S-transferases and their potential as acaricide detoxification proteins.Parasites & vectors · 2015Article
- Identification of 24h Ixodes scapularis immunogenic tick saliva proteins.Ticks and tick-borne diseases · 2015Article
- Tsetse GmmSRPN10 has anti-complement activity and is important for successful establishment of trypanosome infections in the fly midgut.PLoS neglected tropical diseases · 2015Article
- Prevalence of Dermanyssus gallinae (Mesostigmata: Dermanyssidae) in industrial poultry farms in North-East Tunisia.Parasite (Paris, France) · 2013Article
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe worldwide distributed hematophagous poultry red mite Dermanyssus gallinae (De Geer, 1778) is one of the most important pests of poultry. Even though 35 acaricide compounds are available, control of D. gallinae remains difficult due to acaricide resistances as well as food safety regulations. The current study was carried out to identify putative excretory/secretory (pES) proteins of D. gallinae since these proteins play an important role in the host-parasite interaction and therefore represent potential targets for the development of novel intervention strategies. Additionally, putative transmembrane proteins (pTM) of D. gallinae were analyzed as representatives of this protein group also serve as promising targets for new control strategies.
methodsD. gallinae pES and pTM protein prediction was based on putative protein sequences of whole transcriptome data which was parsed to different bioinformatical servers (SignalP, SecretomeP, TMHMM and TargetP). Subsequently, pES and pTM protein sequences were functionally annotated by different computational tools.
resultsComputational analysis of the D. gallinae proteins identified 3,091 pES (5.6%) and 7,361 pTM proteins (13.4%). A significant proportion of pES proteins are considered to be involved in blood feeding and digestion such as salivary proteins, proteases, lipases and carbohydrases. The cysteine proteases cathepsin D and L as well as legumain, enzymes that cleave hemoglobin during blood digestion of the near related ticks, represented 6 of the top-30 BLASTP matches of the poultry red mite's secretome. Identified pTM proteins may be involved in many important biological processes including cell signaling, transport of membrane-impermeable molecules and cell recognition. Ninjurin-like proteins, whose functions in mites are still unknown, represent the most frequently occurring pTM.
conclusionThe current study is the first providing a mite's secretome as well as transmembranome and provides valuable insights into D. gallinae pES and pTM proteins operating in different metabolic pathways. Identifying a variety of molecules putatively involved in blood feeding may significantly contribute to the development of new therapeutic targets or vaccines against this poultry pest.
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