ArticlePloS one2013
Unraveling the evolution of the Atlantic cod's (Gadus morhua L.) alternative immune strategy.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
- Characterization of T-cell receptor loci and expressed repertoire reveals a capacity for robust T-cell response in Atlantic cod (Gadus morhua).Scientific reports · 2026Article
- TLR25 is endosomally located and responds toFrontiers in immunology · 2026Article
- IgM-mediated protection drives early B-cell activation and mucosal containment ofFrontiers in immunology · 2026Article
- Review
- The Atlantic Cod MHC I compartment has the properties needed for cross-presentation in the absence of MHC II.Scientific reports · 2024Article
- Integrative omics-analysis of lipid metabolism regulation by peroxisome proliferator-activated receptor a and b agonists in male Atlantic cod.Frontiers in physiology · 2023Article
- Atlantic cod (Frontiers in cell and developmental biology · 2023Article
- Macroevolutionary foundations of a recently evolved innate immune defense.Evolution; international journal of organic evolution · 2021Article
- Fate of MHCII in salmonids following 4WGD.Immunogenetics · 2021Article
- Innovation in Nucleotide-Binding Oligomerization-Like Receptor and Toll-Like Receptor Sensing Drives the Major Histocompatibility Complex-II Free Atlantic Cod Immune System.Frontiers in immunology · 2020Article
- Single-Cell Transcriptome Profiling of Immune Cell Repertoire of the Atlantic Cod Which Naturally Lacks the Major Histocompatibility Class II System.Frontiers in immunology · 2020Article
- Netting the Stress Responses in Fish.Frontiers in endocrinology · 2019Review
- Article
- Independent losses of a xenobiotic receptor across teleost evolution.Scientific reports · 2018Article
- Genomic architecture of haddock (Melanogrammus aeglefinus) shows expansions of innate immune genes and short tandem repeats.BMC genomics · 2018Article
- Major histocompatibility complex (MHC) fragment numbers alone - in Atlantic cod and in general - do not represent functional variability.F1000Research · 2018Article
- MHC and adaptive immunity in teleost fishes.Immunogenetics · 2017Review
- The evolution of the major histocompatibility complex in upstream versus downstream river populations of the longnose dace.Ecology and evolution · 2017Article
- Linking species habitat and past palaeoclimatic events to evolution of the teleost innate immune system.Proceedings. Biological sciences · 2017Article
- Whole genome sequencing data and de novo draft assemblies for 66 teleost species.Scientific data · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genes encoding the major histocompatibility complex (MHC) have been thought to play a vital role in the adaptive immune system in all vertebrates. The discovery that Atlantic cod (Gadus morhua) has lost important components of the MHC II pathway, accompanied by an unusually high number of MHC I genes, shed new light on the evolution and plasticity of the immune system of teleosts as well as in higher vertebrates. The overall aim of this study was to further investigate the highly expanded repertoire of MHC I genes using a cDNA approach to obtain sequence information of both the binding domains and the sorting signaling potential in the cytoplasmic tail. Here we report a novel combination of two endosomal sorting motifs, one tyrosine-based associated with exogenous peptide presentation by cross-presenting MHCI molecules, and one dileucine-based associated with normal MHC II functionality. The two signal motifs were identified in the cytoplasmic tail in a subset of the genes. This indicates that these genes have evolved MHC II-like functionality, allowing a more versatile use of MHC I through cross-presentation. Such an alternative immune strategy may have arisen through adaptive radiation and acquisition of new gene function as a response to changes in the habitat of its ancestral lineage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.