SynthesisPloS one2013
A meta analysis and hierarchical classification of HU-based atherosclerotic plaque characterization criteria.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Incremental Prognostic Value of Coronary Computed Tomography Angiography: High-Risk Plaque Characteristics in Asymptomatic Patients.Journal of atherosclerosis and thrombosis · 2017Trial
- MG-HGLNet: A Mixed-Grained Hierarchical Geometric-Semantic Learning Framework with Dynamic Prototypes for Coronary Artery Lesions Assessment.Bioengineering (Basel, Switzerland) · 2026Article
- CT-Derived Aortic Plaque Characteristics Predict MRI-Detected Silent Cerebral Infarction after Total Aortic Arch Replacement.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2026Article
- Coronary stenting after aortic root replacement.Radiology case reports · 2025Article
- Association between aortic low-attenuation plaques and the risk of cerebral infarction in hybrid aortic arch repair.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Article
- Plaque characteristics on coronary CT angiography associated with the positive findings of fractional flow reserve and instantaneous wave-free ratio.Heart and vessels · 2021Article
- Machine Learning for Assessment of Coronary Artery Disease in Cardiac CT: A Survey.Frontiers in cardiovascular medicine · 2019Review
- Correction of lumen contrast-enhancement influence on non-calcified coronary atherosclerotic plaque quantification on CT.The international journal of cardiovascular imaging · 2015Article
- A novel method for non-invasive plaque morphology analysis by coronary computed tomography angiography.The international journal of cardiovascular imaging · 2014Article
- BMP4 enhances foam cell formation by BMPR-2/Smad1/5/8 signaling.International journal of molecular sciences · 2014Article
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Authors and funding
5 authors.
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Abstract
backgroundMany computed tomography (CT) studies have reported that lipid-rich, presumably rupture-prone atherosclerotic plaques can be characterized according to their Hounsfield Unit (HU) value. However, the published HU-based characterization criteria vary considerably. The present study aims to systematically analyze these values and empirically derive a hierarchical classification of the HU-based criteria which can be referred in clinical situation. MATERIAL AND
methodsA systematic search in PubMed and Embase for publications with HU-criteria to characterize lipid-rich and fibrous atherosclerotic plaques resulted in 36 publications, published between 1998 and 2011. The HU-criteria were systematically analyzed based on the characteristics of the reporting study. Significant differences between HU-criteria were checked using Student's t-test. Subsequently, a hierarchical classification of HU-criteria was developed based on the respective study characteristics.
resultsNo correlation was found between HU-criteria and the reported lumen contrast-enhancement. Significant differences were found for HU-criteria when pooled according to the respective study characteristics: examination type, vessel type, CT-vendor, detector-rows, voltage-setting, and collimation-width. The hierarchical classification resulted in 21 and 22 CT attenuation value categories, for lipid-rich and fibrous plaque, respectively. More than 50% of the hierarchically classified HU-criteria were significantly different.
conclusionIn conclusion, variations in the reported CT attenuation values for lipid-rich and fibrous plaque are so large that generalized values are unreliable for clinical use. The proposed hierarchical classification can be used to determine reference CT attenuation values of lipid-rich and fibrous plaques for the local setting.
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