ArticlePloS one2013
Dynamic transcript profiling of Candida albicans infection in zebrafish: a pathogen-host interaction study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 64 citations in OpenAlex.
- Potential use of titanium nano-gel to palliate redox status, DNA damage, histopathological changes, and renal-hepatic disorders induced by Candida albicans in Clarias gariepinus.Veterinary research communications · 2025Article
- Nano-chitosan hydrogel alleviates Candida albicans-induced health alterations in Nile tilapia (Oreochromis niloticus): antioxidant response, neuro-behaviors, hepato-renal functions, and histopathological investigation.BMC veterinary research · 2025Article
- Assessment of Biofilm Formation byJournal of fungi (Basel, Switzerland) · 2022Article
- The Zebrafish as a Model Host for Invasive Fungal Infections.Journal of fungi (Basel, Switzerland) · 2018Review
- The other white-nose syndrome transcriptome: Tolerant and susceptible hosts respond differently to the pathogenEcology and evolution · 2017Article
- Dual-species transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions.Scientific reports · 2016Article
- Dissecting Candida albicans Infection from the Perspective of C. albicans Virulence and Omics Approaches on Host-Pathogen Interaction: A Review.International journal of molecular sciences · 2016Review
- In Vivo Transcriptional Profiling of Human Pathogenic Fungi during Infection: Reflecting the Real Life?PLoS pathogens · 2016Review
- Budding off: bringing functional genomics to Candida albicans.Briefings in functional genomics · 2016Review
- Article
- A Genome-Wide Transcriptional Analysis of Yeast-Hyphal Transition in Candida tropicalis by RNA-Seq.PloS one · 2016Article
- Article
- Activation and alliance of regulatory pathways in C. albicans during mammalian infection.PLoS biology · 2015Article
- Novel Approaches for Fungal Transcriptomics from Host Samples.Frontiers in microbiology · 2015Review
- Review
- Integrated inference and evaluation of host-fungi interaction networks.Frontiers in microbiology · 2015Article
- The role of TGF-β signaling and apoptosis in innate and adaptive immunity in zebrafish: a systems biology approach.BMC systems biology · 2014Article
- Studying the immune response to human viral infections using zebrafish.Developmental and comparative immunology · 2014Review
- Utilization of zebrafish for intravital study of eukaryotic pathogen-host interactions.Developmental and comparative immunology · 2014Review
- Robustness analysis on interspecies interaction network for iron and glucose competition between Candida albicans and zebrafish during infection.BMC systems biology · 2014Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Candida albicans is responsible for a number of life-threatening infections and causes considerable morbidity and mortality in immunocompromised patients. Previous studies of C. albicans pathogenesis have suggested several steps must occur before virulent infection, including early adhesion, invasion, and late tissue damage. However, the mechanism that triggers C. albicans transformation from yeast to hyphae form during infection has yet to be fully elucidated. This study used a systems biology approach to investigate C. albicans infection in zebrafish. The surviving fish were sampled at different post-infection time points to obtain time-lapsed, genome-wide transcriptomic data from both organisms, which were accompanied with in sync histological analyses. Principal component analysis (PCA) was used to analyze the dynamic gene expression profiles of significant variations in both C. albicans and zebrafish. The results categorized C. albicans infection into three progressing phases: adhesion, invasion, and damage. Such findings were highly supported by the corresponding histological analysis. Furthermore, the dynamic interspecies transcript profiling revealed that C. albicans activated its filamentous formation during invasion and the iron scavenging functions during the damage phases, whereas zebrafish ceased its iron homeostasis function following massive hemorrhage during the later stages of infection. Most of the immune related genes were expressed as the infection progressed from invasion to the damage phase. Such global, inter-species evidence of virulence-immune and iron competition dynamics during C. albicans infection could be crucial in understanding control fungal pathogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.