ArticlePloS one2013
Geographically structured populations of Cryptococcus neoformans Variety grubii in Asia correlate with HIV status and show a clonal population structure.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
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Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Single nucleotide polymorphisms are associated with strain-specific virulence differences among clinical isolates of Cryptococcus neoformans.Nature communications · 2024Pooled it
- Sequence Types ofPathogens (Basel, Switzerland) · 2026Article
- Molecular Epidemiology and Antifungal Susceptibility ofInfection and drug resistance · 2026Article
- Intrinsic and extrinsic factors affecting the evolution of virulence in the HIV-associated opportunistic human fungal pathogenVirulence · 2025Article
- Rare Case of Systemic Cryptococcal Lymphadenopathy in a Persian Cat.Veterinary medicine and science · 2025Article
- Genomic Characterization ofVeterinary sciences · 2025Article
- Current Approaches in Genome Assembly of Human Fungal Pathogens.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Environmental sources of Cryptococcus neoformans species complex in Kampala, Uganda: A preliminary study.PloS one · 2025Article
- Multi-Locus Sequence Typing-Based Genetic Analysis, Antifungal Resistance, and Clinical Prognosis of Cryptococcus neoformans Infections in HIV-Infected Patients in Northern China.The American journal of tropical medicine and hygiene · 2024Article
- Antifungal susceptibility and multilocus sequence typing (MLST) of Cryptococcus neoformans complex from HIV-associated cryptococcal meningitis patients in Manaus, Amazonas, Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Article
- Molecular epidemiological investigation ofMicrobiology spectrum · 2024Article
- Cryptococcosis with pulmonary cavitation in an immunocompetent child: a case report and literature review.BMC infectious diseases · 2024Review
- Genotyping Analysis ofJournal of fungi (Basel, Switzerland) · 2023Article
- Cryptococcal granulomas of basal ganglia due to Cryptococcus neoformans in a cat: a case report and literature review.The Journal of veterinary medical science · 2023Review
- Importance of Clinical Isolates inJournal of fungi (Basel, Switzerland) · 2023Review
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5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
24 authors at 17 institutions in 12 countries.
Funding
Abstract
Cryptococcosis is an important fungal disease in Asia with an estimated 140,000 new infections annually the majority of which occurs in patients suffering from HIV/AIDS. Cryptococcus neoformans variety grubii (serotype A) is the major causative agent of this disease. In the present study, multilocus sequence typing (MLST) using the ISHAM MLST consensus scheme for the C. neoformans/C. gattii species complex was used to analyse nucleotide polymorphisms among 476 isolates of this pathogen obtained from 8 Asian countries. Population genetic analysis showed that the Asian C. neoformans var. grubii population shows limited genetic diversity and demonstrates a largely clonal mode of reproduction when compared with the global MLST dataset. HIV-status, sequence types and geography were found to be confounded. However, a correlation between sequence types and isolates from HIV-negative patients was observed among the Asian isolates. Observations of high gene flow between the Middle Eastern and the Southeastern Asian populations suggest that immigrant workers in the Middle East were originally infected in Southeastern Asia.
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