ArticlePloS one2013
Ovarian volume throughout life: a validated normative model.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Single-nucleus profiling reveals age-associated remodeling opposed by parity in the postmenopausal human ovary.bioRxiv : the preprint server for biology · 2026Article
- The human ovarian reserve: the narrative and the science.Human reproduction update · 2026Review
- Artificial Intelligence-Based Approach for Automated Gonad Volume Quantification Using Magnetic Resonance Imaging in Healthy Adolescents Across Puberty.Diagnostics (Basel, Switzerland) · 2026Article
- Mechanisms of Phthalate-Induced Accelerated Ovarian Aging in Experimental Models.Current environmental health reports · 2026Review
- Ovarian antral follicle dynamics from birth through reproductive maturity: a mini-review.Frontiers in endocrinology · 2026Review
- The value of anti-Mullerian hormone for diagnosing polycystic ovary syndrome in adolescents: a case-control study based on an epidemiological survey.Frontiers in reproductive health · 2026Article
- Ultrasound modalities and age-specific normative findings in pediatric and adolescent gynecology.Frontiers in reproductive health · 2026Review
- Female Reproductive Tract Modeling through Advanced 3D Biomimetic Platforms.Biomaterials research · 2026Review
- Sonographic normative range of uterine and ovarian dimensions and their correlation with anthropometric and hormonal parameters among Indian women of reproductive age (18-40) years.Frontiers in medicine · 2026Article
- Ultrasound radiomics and deep learning for predicting antral follicle count and anti-Müllerian hormone.Scientific reports · 2025Article
- Polycystic Ovary Syndrome - Support and Prevention in Adolescence.Geburtshilfe und Frauenheilkunde · 2025Article
- Associations of fetal and infant growth with pubertal timing.Archives of disease in childhood · 2025Article
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- International evidence-based recommendations for polycystic ovary syndrome in adolescents.BMC medicine · 2025Review
- Kidney disease and reproductive health.Nature reviews. Nephrology · 2025Review
- The functional ovarian anatomy of 492 women aged 18-22 years: a population-based study in Norway.Human reproduction open · 2025Article
- [Ovarian masses in infants and children].Radiologie (Heidelberg, Germany) · 2024Review
Corrections and comments
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Authors and funding
7 authors.
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Abstract
The measurement of ovarian volume has been shown to be a useful indirect indicator of the ovarian reserve in women of reproductive age, in the diagnosis and management of a number of disorders of puberty and adult reproductive function, and is under investigation as a screening tool for ovarian cancer. To date there is no normative model of ovarian volume throughout life. By searching the published literature for ovarian volume in healthy females, and using our own data from multiple sources (combined n=59,994) we have generated and robustly validated the first model of ovarian volume from conception to 82 years of age. This model shows that 69% of the variation in ovarian volume is due to age alone. We have shown that in the average case ovarian volume rises from 0.7 mL (95% CI 0.4-1.1 mL) at 2 years of age to a peak of 7.7 mL (95% CI 6.5-9.2 mL) at 20 years of age with a subsequent decline to about 2.8 mL (95% CI 2.7-2.9 mL) at the menopause and smaller volumes thereafter. Our model allows us to generate normal values and ranges for ovarian volume throughout life. This is the first validated normative model of ovarian volume from conception to old age; it will be of use in the diagnosis and management of a number of diverse gynaecological and reproductive conditions in females from birth to menopause and beyond.
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