ArticleResearch in pharmaceutical sciences2013
Antispasmodic effects of Prangos ferulacea acetone extract and its main component osthole on ileum contraction.
Article in Research in pharmaceutical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Essential Oil ofPlants (Basel, Switzerland) · 2026Review
- Optimizing the eco-friendly dyeing of wool and nylon fabrics with Prangos ferulacea (L.) Lindl using artificial intelligence.Scientific reports · 2025Article
- Prangos ferulacea (L.) ameliorates behavioral alterations, hippocampal oxidative stress markers, and apoptotic deficits in a rat model of autism induced by valproic acid.Brain and behavior · 2023Article
- Chemical Composition and Biological Activities ofMolecules (Basel, Switzerland) · 2022Article
- Antispasmodic Potential of Medicinal Plants: A Comprehensive Review.Oxidative medicine and cellular longevity · 2021Review
- Review
- Natural Antispasmodics: Source, Stereochemical Configuration, and Biological Activity.BioMed research international · 2018Review
- Isolation of Phenolic Derivatives and Essential Oil Analysis ofIranian journal of pharmaceutical research : IJPR · 2017Article
- Osthole suppresses the migratory ability of human glioblastoma multiforme cells via inhibition of focal adhesion kinase-mediated matrix metalloproteinase-13 expression.International journal of molecular sciences · 2014Article
- Comparative Evaluation of Cytotoxic and Apoptogenic Effects of Several Coumarins on Human Cancer Cell Lines: Osthole Induces Apoptosis in p53-Deficient H1299 Cells.Advances in pharmacological sciences · 2014Article
- p53 is a key regulator for osthole-triggered cancer pathogenesis.BioMed research international · 2014Article
- Osthole attenuates doxorubicin-induced apoptosis in PC12 cells through inhibition of mitochondrial dysfunction and ROS production.BioMed research international · 2014Article
- Studies of the interaction between isoimperatorin and human serum albumin by multispectroscopic method: identification of possible binding site of the compound using esterase activity of the protein.TheScientificWorldJournal · 2013Article
- Evaluation of anti-spasmodic effect of Peucedanum pastinacifolium extracts on rat's ileum.Research in pharmaceutical sciencesArticle
- Antispasmodic effect of Dracocephalum kotschyi hydroalcoholic extract on rat ileum contraction.Research in pharmaceutical sciencesArticle
- Assessment of hydroalcoholic extract of seeds and leaves of Moringa peregrina on ileum spasm.Research in pharmaceutical sciencesArticle
- Comparison of antispasmodic effects of Dracocephalum kotschyi essential oil, limonene and α-terpineol.Research in pharmaceutical sciencesArticle
- Antispasmodic and antidiarrhoeal activities of 6-(4-hydroxy-3-methoxyphenyl)-hexanonic acid from Pycnocycla spinosa Decne. exBoiss.Research in pharmaceutical sciencesArticle
- Antispasmodic activity of isovanillin and isoacetovanillon in comparison with Pycnocycla spinosa Decne.exBoiss extract on rat ileum.Research in pharmaceutical sciencesArticle
- Antidiarrheal activities of isovanillin, iso-acetovanillon and Pycnocycla spinosa Decne ex.Boiss extract in mice.Research in pharmaceutical sciencesArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prangos ferulacea is a plant found in the Mediterranean and Middle-east regions used as carminative, anti-flatulent, emollient and antibacterial herb. It is believed that the coumarins are responsible for some of known effects of Prangos. In this research the relaxant effects of P. ferulacea coumrin rich extract as well as osthole as its main prenylated coumarins were investigated on rat ileum contraction in vitro. Relaxant effect of osthole and P. ferulacea extract were examined on contraction induced by KCl, acetylcholine (ACh) and electrical field stimulation (EFS) and compared with propantheline and nifedipine. The acetone extract of P. ferulacea concentration-dependently relaxed ileum contraction induced by KCl (IC50=1.3 ± 0.25 μg/ml), ACh (IC50=7.7 ± 1.1 μg/ml) and EFS (IC50=8.8 ± 1.4 μg/ml), while, the extract at lower concentration (4 μg/ml) potentiated the ACh and EFS responses. Unlike the extract, osthole did not potentiate the ileum contraction but concentration-dependently inhibited ileum contractile responses to KCl (IC50=2.2 ± 0.7 μg/ml), ACh (IC50=2.5 ± 0.7 μg/ml) and EFS (IC50=2.8 ± 0.24 μg/ml). Propantheline concentration dependently inhibited the ileum response to ACh, with IC50 value of 0.61 ± 0.09nM without affecting the KCl response. As expected, the EFS response was only partially reduced. Nifedipine (0.2-50 nM) inhibited tonic contraction induced by KCl with IC50 value of 2.5 ± 0.8 nM but only partially inhibited the response to ACh. However, the response to EFS was reduced only by 33%. These results confirmed both potentiatory and inhibitory action of P. ferulacea extract on rat ileum contractile activity. Osthole is responsible for the inhibitory effect but potentiating components are not yet known.
Indexed as
Identifiers
24019823PMC3764677W2099586515What OpenQuestion holds
Registered trials
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