ArticleProceedings of the National Academy of Sciences of the United States of America2013
Presynaptic gating of excitation in the dorsal raphe nucleus by GABA.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Maturation of glutamatergic transmission onto dorsal raphe serotonergic neurons.Journal of neurophysiology · 2024Article
- Requisite role of dorsal raphé in contextual cocaine-memory reconsolidation.Neuropharmacology · 2024Article
- Divergent modulation of pain and anxiety by GABAergic neurons in the ventrolateral periaqueductal gray and dorsal raphe.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- The connectome of an insect brain.Science (New York, N.Y.) · 2023Article
- Restraint Stress and Repeated Corticosterone Administration Differentially Affect Neuronal Excitability, Synaptic Transmission and 5-HTInternational journal of molecular sciences · 2022Article
- Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food.Nature communications · 2022Article
- Axo-axonic synapses: Diversity in neural circuit function.The Journal of comparative neurology · 2021Review
- Serotonergic Axons as Fractional Brownian Motion Paths: Insights Into the Self-Organization of Regional Densities.Frontiers in computational neuroscience · 2020Article
- Direction of action of presynaptic GABAJournal of neurophysiology · 2019Article
- Ketamine Administration Reverses Corticosterone-Induced Alterations in Excitatory and Inhibitory Transmission in the Rat Dorsal Raphe Nucleus.Neural plasticity · 2019Article
- Polymorphic computation in locus coeruleus networks.Nature neuroscience · 2017Article
- Mapping the connectivity of serotonin transporter immunoreactive axons to excitatory and inhibitory neurochemical synapses in the mouse limbic brain.Brain structure & function · 2017Article
- Dynamic Changes in Amygdala Psychophysiological Connectivity Reveal Distinct Neural Networks for Facial Expressions of Basic Emotions.Scientific reports · 2017Article
- Inactivation of GIRK channels weakens the pre- and postsynaptic inhibitory activity in dorsal raphe neurons.Physiological reports · 2017Article
- Shifted pallidal co-release of GABA and glutamate in habenula drives cocaine withdrawal and relapse.Nature neuroscience · 2016Article
- Biphasic modulation of parallel fibre synaptic transmission by co-activation of presynaptic GABAA and GABAB receptors in mice.The Journal of physiology · 2016Article
- ON and OFF retinal ganglion cells differentially regulate serotonergic and GABAergic activity in the dorsal raphe nucleus.Scientific reports · 2016Article
- Dorsal raphe nucleus projecting retinal ganglion cells: Why Y cells?Neuroscience and biobehavioral reviews · 2015Review
- Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Functional alterations in the dorsal raphe nucleus following acute and chronic ethanol exposure.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The dorsal raphe nucleus (DR) controls forebrain serotonin neurotransmission to influence emotional states. GABA neurotransmission in the DR has been implicated in regulating sleep/wake states and influencing anxiety and aggression. To gain insight into how GABA regulates DR activity, we analyzed the organization of both GABA and glutamate axons in the rat DR using a high-resolution immunofluorescence technique, array tomography, as well as EM. This analysis revealed that a third or more of GABA-containing axons are organized in synaptic triads with a glutamatergic axon and a common postsynaptic target. Electrophysiological recordings showed that GABA has the capacity to presynaptically gate glutamate release in the DR through a combination of GABA-A and GABA-B receptor-mediated effects. Thus, GABA-glutamate synaptic triads are a common feature of the network architecture of the DR with the potential to regulate excitation of the nucleus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.