ArticleMolecular & cellular proteomics : MCP2013
New Arabidopsis thaliana cytochrome c partners: a look into the elusive role of cytochrome c in programmed cell death in plants.
Article in Molecular & cellular proteomics : MCP, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 62 citations in OpenAlex.
- Perception and processing of stress signals by plant mitochondria.The Plant journal : for cell and molecular biology · 2024Review
- Genome-Wide Association Study Identified Novel SNPs Associated with Chlorophyll Content in Maize.Genes · 2023Article
- Phosphorylation disrupts long-distance electron transport in cytochrome c.Nature communications · 2022Article
- Lysosomes: multifunctional compartments ruled by a complex regulatory network.FEBS open bio · 2022Review
- Structural and functional insights into lysine acetylation of cytochrome c using mimetic point mutants.FEBS open bio · 2021Article
- Mitochondrial cytochrome c shot towards histone chaperone condensates in the nucleus.FEBS open bio · 2021Review
- Apoptosis is not conserved in plants as revealed by critical examination of a model for plant apoptosis-like cell death.BMC biology · 2021Article
- Cellular oxidative stress in programmed cell death: focusing on chloroplasticJournal of plant research · 2021Article
- CytochromePlants (Basel, Switzerland) · 2021Article
- Voltage-Dependent Anion-Selective Channels and Other Mitochondrial Membrane Proteins Form Diverse Complexes in Beetroots Subjected to Flood-Induced Programmed Cell Death.Frontiers in plant science · 2021Article
- Post-Translational Modifications of CytochromeInternational journal of molecular sciences · 2020Review
- Stress signalling dynamics of the mitochondrial electron transport chain and oxidative phosphorylation system in higher plants.Annals of botany · 2020Review
- Exploring protein phosphorylation by combining computational approaches and biochemical methods.Computational and structural biotechnology journal · 2020Article
- Wheel and Deal in the Mitochondrial Inner Membranes: The Tale of CytochromeOxidative medicine and cellular longevity · 2020Review
- Oxidative stress is tightly regulated by cytochromeProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition.Cell death & disease · 2018Article
- Emerging roles of chromatin in the maintenance of genome organization and function in plants.Genome biology · 2017Review
- Structural basis of mitochondrial dysfunction in response to cytochromeProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Histone chaperone activity of Arabidopsis thaliana NRP1 is blocked by cytochrome c.Nucleic acids research · 2017Article
- Melatonin Protects Cultured Tobacco Cells against Lead-Induced Cell DeathFrontiers in plant science · 2017Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Programmed cell death is an event displayed by many different organisms along the evolutionary scale. In plants, programmed cell death is necessary for development and the hypersensitive response to stress or pathogenic infection. A common feature in programmed cell death across organisms is the translocation of cytochrome c from mitochondria to the cytosol. To better understand the role of cytochrome c in the onset of programmed cell death in plants, a proteomic approach was developed based on affinity chromatography and using Arabidopsis thaliana cytochrome c as bait. Using this approach, ten putative new cytochrome c partners were identified. Of these putative partners and as indicated by bimolecular fluorescence complementation, nine of them bind the heme protein in plant protoplasts and human cells as a heterologous system. The in vitro interaction between cytochrome c and such soluble cytochrome c-targets was further corroborated using surface plasmon resonance. Taken together, the results obtained in the study indicate that Arabidopsis thaliana cytochrome c interacts with several distinct proteins involved in protein folding, translational regulation, cell death, oxidative stress, DNA damage, energetic metabolism, and mRNA metabolism. Interestingly, some of these novel Arabidopsis thaliana cytochrome c-targets are closely related to those for Homo sapiens cytochrome c (Martínez-Fábregas et al., unpublished). These results indicate that the evolutionarily well-conserved cytosolic cytochrome c, appearing in organisms from plants to mammals, interacts with a wide range of targets on programmed cell death. The data have been deposited to the ProteomeXchange with identifier PXD000280.
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