ArticleEndoscopy2013
Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening.
Article in Endoscopy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Aberrant p53 Immunostaining in Barrett's Esophagus Predicts Neoplastic Progression: Systematic Review and Meta-Analyses.Digestive diseases and sciences · 2019Pooled it
- Probing Field Cancerization in the Gastrointestinal Tract Using a Hybrid Raman and Partial Wave Spectroscopy Microscope.Analytical chemistry · 2025Article
- Global, regional, and national epidemiology and risk factors of geriatric digestive system cancers from 1990 to 2021.Frontiers in public health · 2025Article
- Dual Photonics Probing of Nano- to Submicron-Scale Structural Alterations in Human Brain Tissues/Cells and Chromatin/DNA with the Progression of Alzheimer's Disease.International journal of molecular sciences · 2024Article
- Convolutional neural network-based regression analysis to predict subnuclear chromatin organization from two-dimensional optical scattering signals.Journal of biomedical optics · 2024Article
- Early detection of lung cancer using artificial intelligence-enhanced optical nanosensing of chromatin alterations in field carcinogenesis.Scientific reports · 2023Article
- Multiscale optical phase fluctuations link disorder strength and fractal dimension of cell structure.Biophysical journal · 2023Article
- Assessment of internal refractive index profile of stochastically inhomogeneous nuclear models via analysis of two-dimensional optical scattering patterns.Journal of biomedical optics · 2021Article
- Disordered chromatin packing regulates phenotypic plasticity.Science advances · 2020Article
- Tissue spatial correlation as cancer marker.Journal of biomedical optics · 2019Article
- Optical pre-screening for laryngeal cancer using reflectance spectroscopy of the buccal mucosa.Biomedical optics express · 2018Article
- Optical detection of field cancerization in the buccal mucosa of patients with esophageal cancer.Clinical and translational gastroenterology · 2018Article
- Disorder strength measured by quantitative phase imaging as intrinsic cancer marker in fixed tissue biopsies.PloS one · 2018Article
- Macrogenomic engineering via modulation of the scaling of chromatin packing density.Nature biomedical engineering · 2017Article
- The transformation of the nuclear nanoarchitecture in human field carcinogenesis.Future science OA · 2017Review
- Review of interferometric spectroscopy of scattered light for the quantification of subdiffractional structure of biomaterials.Journal of biomedical optics · 2017Review
- Metabolomic Evidence for a Field Effect in Histologically Normal and Metaplastic Tissues in Patients with Esophageal Adenocarcinoma.Neoplasia (New York, N.Y.) · 2017Article
- The Global Relationship between Chromatin Physical Topology, Fractal Structure, and Gene Expression.Scientific reports · 2017Article
- Procedures for risk-stratification of lung cancer using buccal nanocytology.Biomedical optics express · 2016Article
- Nanoscale refractive index fluctuations detected via sparse spectral microscopy.Biomedical optics express · 2016Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND STUDY
aimsEsophageal adenocarcinoma (EAC) has a dismal prognosis unless treated early or prevented at the precursor stage of Barrett's esophagus-associated dysplasia. However, some patients with cancer or dysplastic Barrett's esophagus (DBE) may not be captured by current screening and surveillance programs. Additional screening techniques are needed to determine who would benefit from endoscopic screening or surveillance. Partial wave spectroscopy (PWS) microscopy (also known as nanocytology) measures the disorder strength (Ld ), a statistic that characterizes the spatial distribution of the intracellular mass at the nanoscale level and thus provides insights into the cell nanoscale architecture beyond that which is revealed by conventional microscopy. The aim of the present study was to compare the disorder strength measured by PWS in normal squamous epithelium in the proximal esophagus to determine whether nanoscale architectural differences are detectable in the field area of EAC and Barrett's esophagus.
methodsDuring endoscopy, proximal esophageal squamous cells were obtained by brushings and were fixed in alcohol and stained with standard hematoxylin and Cyto-Stain. The disorder strength of these sampled squamous cells was determined by PWS.
resultsA total of 75 patient samples were analyzed, 15 of which were pathologically confirmed as EAC, 13 were DBE, and 15 were non-dysplastic Barrett's esophagus; 32 of the patients, most of whom had reflux symptoms, acted as controls. The mean disorder strength per patient in cytologically normal squamous cells in the proximal esophagus of patients with EAC was 1.79-times higher than that of controls (P<0.01). Patients with DBE also had a disorder strength 1.63-times higher than controls (P<0.01).
conclusionIntracellular nanoarchitectural changes were found in the proximal squamous epithelium in patients harboring distal EAC and DBE using PWS. Advances in this technology and the biological phenomenon of the field effect of carcinogenesis revealed in this study may lead to a useful tool in non-invasive screening practices in DBE and EAC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.