ArticleSensors (Basel, Switzerland)2013
Application of a novel tool for diagnosing bile acid diarrhoea.
Article in Sensors (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- The Diagnostic Utility of Volatile Organic Compounds in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.Journal of Crohn's & colitis · 2024Pooled it
- Medical diagnosis at the point-of-care by portable high-field asymmetric waveform ion mobility spectrometry: a systematic review and meta-analysis.Journal of breath research · 2021Pooled it
- Guideline
- Bile Acid Diarrhea: From Molecular Mechanisms to Clinical Diagnosis and Treatment in the Era of Precision Medicine.International journal of molecular sciences · 2024Review
- Nanotechnology and E-Sensing for Food Chain Quality and Safety.Sensors (Basel, Switzerland) · 2023Review
- Machine learning and signal processing assisted differential mobility spectrometry (DMS) data analysis for chemical identification.Analytical methods : advancing methods and applications · 2022Article
- Article
- Minimal Gluten Exposure Alters Urinary Volatile Organic Compounds in Stable Coeliac Disease.Sensors (Basel, Switzerland) · 2022Article
- In-Field Detection of American Foulbrood (AFB) by Electric Nose Using Classical Classification Techniques and Sequential Neural Networks.Sensors (Basel, Switzerland) · 2022Article
- Identification of Specific Substances in the FAIMS Spectra of Complex Mixtures Using Deep Learning.Sensors (Basel, Switzerland) · 2021Article
- Bile acid diarrhoea: pathophysiology, diagnosis and management.Frontline gastroenterology · 2021Article
- Development of a Tuneable NDIR Optical Electronic Nose.Sensors (Basel, Switzerland) · 2020Article
- The pathophysiology of bile acid diarrhoea: differences in the colonic microbiome, metabolome and bile acids.Scientific reports · 2020Article
- Gas Sensors Based on Chemi-Resistive Hybrid Functional Nanomaterials.Nano-micro letters · 2020Review
- Pre-analytical and analytical variables that influence urinary volatile organic compound measurements.PloS one · 2020Article
- Electronic nose to distinguish bladder cancer by urinary odour feature: A pilot study.Cancer biomarkers : section A of Disease markers · 2020Article
- Discrimination of Different Species of Dendrobium with an Electronic Nose Using Aggregated Conformal Predictor.Sensors (Basel, Switzerland) · 2019Article
- Non-Invasive Diagnosis of Diabetes by Volatile Organic Compounds in Urine Using FAIMS and Fox4000 Electronic Nose.Biosensors · 2018Article
- Discrimination between Alternative Herbal Medicines from Different Categories with the Electronic Nose.Sensors (Basel, Switzerland) · 2018Article
- Application of Electronic-Nose Technologies and VOC-Biomarkers for the Noninvasive Early Diagnosis of Gastrointestinal DiseasesSensors (Basel, Switzerland) · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bile acid diarrhoea (BAD) is a common disease that requires expensive imaging to diagnose. We have tested the efficacy of a new method to identify BAD, based on the detection of differences in volatile organic compounds (VOC) in urine headspace of BAD vs. ulcerative colitis and healthy controls. A total of 110 patients were recruited; 23 with BAD, 42 with ulcerative colitis (UC) and 45 controls. Patients with BAD also received standard imaging (Se75HCAT) for confirmation. Urine samples were collected and the headspace analysed using an AlphaMOS Fox 4000 electronic nose in combination with an Owlstone Lonestar Field Asymmetric Ion Mobility Spectrometer (FAIMS). A subset was also tested by gas chromatography, mass spectrometry (GCMS). Linear Discriminant Analysis (LDA) was used to explore both the electronic nose and FAIMS data. LDA showed statistical differences between the groups, with reclassification success rates (using an n-1 approach) at typically 83%. GCMS experiments confirmed these results and showed that patients with BAD had two chemical compounds, 2-propanol and acetamide, that were either not present or were in much reduced quantities in the ulcerative colitis and control samples. We believe that this work may lead to a new tool to diagnose BAD, which is cheaper, quicker and easier that current methods.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.