Evidence map›Paper›PMID 24018851›Full record

ReviewLeukemia2014

Very small embryonic-like stem cells (VSELs) represent a real challenge in stem cell biology: recent pros and cons in the midst of a lively debate.

M Z Ratajczak, E Zuba-Surma, W Wojakowski, M Suszynska, K Mierzejewska, R Liu, J Ratajczak, D M Shin, M Kucia

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Leukemia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 101 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. The Endometrial Stem/Progenitor Cells and Their Niches.Stem cell reviews and reports · 2024
    Review
  5. Review
  6. Review
  7. Frontiers in cell and developmental biology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

M Z RatajczakStem Cell Institute at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
E Zuba-SurmaDepartment of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
W WojakowskiThird Department of Cardiology, Silesian Medical University, Katowice, Poland.
M SuszynskaStem Cell Institute at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
K MierzejewskaDepartment of Physiology, Pomeranian Medical University, Szczecin, Poland.
R LiuStem Cell Institute at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
J Ratajczak1] Stem Cell Institute at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA [2] Department of Physiology, Pomeranian Medical University, Szczecin, Poland.
D M ShinDepartment of Biomedical Sciences, University of Ulsan College of Medicine, Seoul, Korea.
M Kucia1] Stem Cell Institute at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA [2] Department of Physiology, Pomeranian Medical University, Szczecin, Poland.
University of Louisville · USJagiellonian University · PLJames Graham Brown Foundation · USMedical University of Silesia · PLPomeranian Medical University · PLUniversity of Ulsan · KR

Funding

Novel mechanisms involving complement cascade in stem cell traffickingR01DK074720 · NIDDK · UNIVERSITY OF LOUISVILLE · PI RATAJCZAK, MARIUSZ Z · 2007 to 2020
$4.1M
NIDDK NIH HHS R01 DK074720
6 · The paper itself

Abstract

The concept that adult tissue, including bone marrow (BM), contains early-development cells with broader differentiation potential has again been recently challenged. In response, we would like to review the accumulated evidence from several independent laboratories that adult tissues, including BM, harbor a population of very rare stem cells that may cross germ layers in their differentiation potential. Thus, the BM stem cell compartment hierarchy needs to be revisited. These dormant, early-development cells that our group described as very small embryonic-like stem cells (VSELs) most likely overlap with similar populations of stem cells that have been identified in adult tissues by other investigators as the result of various experimental strategies and have been given various names. As reported, murine VSELs have some pluripotent stem cell characteristics. Moreover, they display several epiblast/germline markers that suggest their embryonic origin and developmental deposition in adult BM. Moreover, at the molecular level, changes in expression of parentally imprinted genes (for example, Igf2-H19) and resistance to insulin/insulin-like growth factor signaling (IIS) regulates their quiescent state in adult tissues. In several emergency situations related to organ damage, VSELs can be activated and mobilized into peripheral blood, and in appropriate animal models they contribute to tissue organ/regeneration. Interestingly, their number correlates with lifespan in mice, and they may also be involved in some malignancies. VSELs have been successfully isolated in several laboratories; however, some investigators experience problems with their isolation.

Indexed as

AnimalsCell DifferentiationEmbryonic Stem CellsEpigenesis, GeneticGenomic ImprintingMice

Identifiers

PMID24018851
PMCPMC3948156
OpenAlexW2004895163

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.