ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2014
Differential ubiquitin-proteasome and autophagy signaling following rotator cuff tears and suprascapular nerve injury.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Skeletal muscle overuse injury: pathophysiological mechanisms, molecular pathways, and rehabilitation strategies.Frontiers in physiology · 2026Review
- Pathophysiological Aspects of Muscle Atrophy and Osteopenia Induced by Chronic Constriction Injury (CCI) of the Sciatic Nerve in Rats.International journal of molecular sciences · 2023Article
- The pathology of oxidative stress-induced autophagy in a chronic rotator cuff enthesis tear.Frontiers in physiology · 2023Review
- Article
- Translational therapy from preclinical animal models for muscle degeneration after rotator cuff injury.Journal of orthopaedic translation · 2022Review
- Reversal of Fatty Infiltration After Suprascapular Nerve Compression Release Is Dependent on UCP1 Expression in Mice.Clinical orthopaedics and related research · 2018Article
- Impaired contractile function of the supraspinatus in the acute period following a rotator cuff tear.BMC musculoskeletal disorders · 2017Article
- The Rotator Cuff Organ: Integrating Developmental Biology, Tissue Engineering, and Surgical Considerations to Treat Chronic Massive Rotator Cuff Tears.Tissue engineering. Part B, Reviews · 2017Article
- Inhibition of prolyl 4-hydroxylase decreases muscle fibrosis following chronic rotator cuff tear.Bone & joint research · 2017Article
- Cathepsins in Rotator Cuff Tendinopathy: Identification in Human Chronic Tears and Temporal Induction in a Rat Model.Annals of biomedical engineering · 2015Article
- The role of the peripheral and central nervous systems in rotator cuff disease.Journal of shoulder and elbow surgery · 2015Review
- Architectural and biochemical adaptations in skeletal muscle and bone following rotator cuff injury in a rat model.The Journal of bone and joint surgery. American volume · 2015Article
- Upregulation of transforming growth factor-β signaling in a rat model of rotator cuff tears.Journal of shoulder and elbow surgery · 2014Article
- Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy.Muscles, ligaments and tendons journal · 2014Article
- Bone morphogenetic protein signaling in rotator cuff muscle atrophy and fatty infiltration.Muscles, ligaments and tendons journalArticle
- Muscle atrophy and fatty infiltration after an acute rotator cuff repair in a sheep model.Muscles, ligaments and tendons journalArticle
- Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy.Muscles, ligaments and tendons journalArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Previous studies have evaluated role of Akt/mTOR signaling in rotator cuff muscle atrophy and determined that there was differential in signaling following tendon transection (TT) and suprascapular nerve (SSN) denervation (DN), suggesting that atrophy following TT and DN was modulated by different protein degradation pathways. In this study, two muscle proteolytic systems that have been shown to be potent regulators of muscle atrophy in other injury models, the ubiquitin-proteasome pathway and autophagy, were evaluated following TT and DN. In addition to examining protein degradation, this study assessed protein synthesis rate following these two surgical models to understand how the balance between protein degradation and synthesis results in atrophy following rotator cuff injury. In contrast to the traditional theory that protein synthesis is decreased during muscle atrophy, this study suggests that protein synthesis is up-regulated in rotator cuff muscle atrophy following both surgical models. While the ubiquitin-proteasome pathway was a major contributor to the atrophy seen following DN, autophagy was a major contributor following TT. The findings of this study suggest that protein degradation is the primary factor contributing to atrophy following rotator cuff injury. However, different proteolytic pathways are activated if SSN injury is involved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.