Evidence map›Paper›PMID 24018384›Full record

ReviewNature reviews. Microbiology2013

The ins and outs of hepatitis C virus entry and assembly.

Brett D Lindenbach, Charles M Rice

Abstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 201 papers.

0numbers the graph read from it
0cells of the map it votes in
201citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

201 citing papers in PubMed.

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141 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Brett D LindenbachDepartment of Microbial Pathogenesis, Yale University, New Haven, Connecticut 06536, USA.
Charles M Rice

Funding

TRANSFORMING TRANSLATIONAL SCIENCE AND EDUCATION TO BENEFIT HUMAN HEALTHUL1RR024143 · NCRR · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY · 2006 to 2011
$49.1M
Modeling human hepatotropic infections in complex tissue organoidsR01DK085713 · NIDDK · ROCKEFELLER UNIVERSITY · PI BHATIA, SANGEETA N., RICE, CHARLES M · 2009 to 2013
$5.6M
Structure and function of the HCV RNA replicaseR01CA057973 · NCI · WASHINGTON UNIVERSITY · PI RICE, CHARLES M · 1992 to 2013
$4.7M
Identification and characterization of cellular factors involved in HCV entryR01AI072613 · NIAID · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2007 to 2016
$4.7M
Molecular determinants of hepatitis C virus assemblyR01AI087925 · NIAID · YALE UNIVERSITY · PI LINDENBACH, BRETT D. · 2010 to 2020
$4.1M
Hepatitis C antivirals: Mechanism of action, combination efficacy and resistanceR01AI099284 · NIAID · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2012 to 2016
$3.6M
Structure and function of the HCV replication complexR01AI089826 · NIAID · YALE UNIVERSITY · PI LINDENBACH, BRETT D., PYLE, ANNA MARIE · 2010 to 2014
$2.9M
Role of HCV p7 and NS2 in infectious virus productionR01AI075099 · NIAID · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2008 to 2012
$2.1M
Simianizing hepatitis C: Defining the species-tropism of a hepatotropic virusR01AI090055 · NIAID · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2010 to 2014
$2.1M
Molecular determinants of hepatitis C virus infectivityR01AI076259 · NIAID · YALE UNIVERSITY · PI LINDENBACH, BRETT D. · 2009 to 2012
$1.6M
NCI NIH HHS CA057973NCI NIH HHS R01 CA057973NCRR NIH HHS UL1 RR024143NCRR NIH HHS UL1RR024143NIAID NIH HHS AI072613NIAID NIH HHS AI075099NIAID NIH HHS AI076259NIAID NIH HHS AI087925NIAID NIH HHS AI089826NIAID NIH HHS AI090055NIAID NIH HHS AI099284NIAID NIH HHS R01 AI072613NIAID NIH HHS R01 AI075099NIAID NIH HHS R01 AI076259NIAID NIH HHS R01 AI087925NIAID NIH HHS R01 AI089826NIAID NIH HHS R01 AI090055NIAID NIH HHS R01 AI099284NIDDK NIH HHS DK085713NIDDK NIH HHS R01 DK085713
6 · The paper itself

Abstract

Hepatitis C virus, a major human pathogen, produces infectious virus particles with several unique features, such as an ability to interact with serum lipoproteins, a dizzyingly complicated process of virus entry, and a pathway of virus assembly and release that is closely linked to lipoprotein secretion. Here, we review these unique features, with an emphasis on recent discoveries concerning virus particle structure, virus entry and virus particle assembly and release.

Indexed as

Virus AssemblyVirus InternalizationAnimalsEndosomesHepacivirusHepatitis CHumansMiceModels, BiologicalReceptors, VirusTetraspanin 28Viral Envelope ProteinsVirus ReleaseCd81 protein, mouseglycoprotein E2, Hepatitis C virusReceptors, VirusTetraspanin 28Viral Envelope Proteins

Identifiers

PMID24018384
PMCPMC3897199

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.