ArticleJournal of muscle research and cell motility1990
Subcellular localization of newly incorporated myosin in rabbit fast skeletal muscle undergoing stimulation-induced type transformation.
Article in Journal of muscle research and cell motility, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Effect of neuromuscular electrical stimulation on skeletal muscle size and function in patients with breast cancer receiving chemotherapy.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Trial
- Paradigm shifts: how electrical stimulation opened up new avenues in science and medicine.European journal of translational myology · 2025Article
- Random myosin loss along thick-filaments increases myosin attachment time and the proportion of bound myosin heads to mitigate force decline in skeletal muscle.Archives of biochemistry and biophysics · 2014Article
- Skeletal muscle myofilament adaptations to aging, disease, and disuse and their effects on whole muscle performance in older adult humans.Frontiers in physiology · 2014Review
- Mechanisms underlying skeletal muscle weakness in human heart failure: alterations in single fiber myosin protein content and function.Circulation. Heart failure · 2009Article
- Adaptive conditioning of skeletal muscle in a large animal model (Sus domesticus).Journal of anatomy · 2006Article
- Myosin isoform transitions in four rabbit muscles during postnatal growth.Journal of muscle research and cell motility · 1996Article
- Isomyosin patterns of single type IIB, IID and IIA fibres from rabbit skeletal muscle.Journal of muscle research and cell motility · 1995Article
- Effects of chronic low frequency stimulation on structural and metabolic properties of hindlimb suspended rat soleus muscle.European journal of applied physiology and occupational physiology · 1995Article
- Myosin heavy-chain mRNA is present in both myofibrillar and subsarcolemmal regions of muscle fibres.The Biochemical journal · 1991Article
- Developmental myosin heavy chain progression in avian type IIB muscle fibres.Journal of muscle research and cell motility · 1991Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Immunogold labelling was used to study the distribution of newly synthesized slow muscle myosin (SM) at the ultrastructural level as it replaced fast muscle myosin (FM) in rabbit muscles undergoing stimulation-induced type transformation. Control fast muscle was labelled strongly with antibody to FM and control slow muscle with antibody to SM; label was confined to the A-band. Well-defined differences in the distribution of label within the A-band suggested that the monoclonal antibodies used corresponded to epitopes on different parts of the myosin molecule; this was confirmed by Western blots of subfragments prepared from FM and SM. After 4 weeks of continuous stimulation at 10 Hz, fibres of the tibialis anterior muscle reacted with antibodies to both isoforms; after 6 weeks, labelling was obtained only with antibody to SM. After a 7-week period of stimulation and 3 further weeks of recovery, fibres again reacted with both antibodies. In all positively-labelled sections, the distribution of gold particles was characteristic of the antibody and independent of the origin or history of the fibres. This observation supports the conclusion that newly synthesized myosin is capable of being incorporated throughout the length and cross-section of the A-band.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.