ArticleThe journal of headache and pain2013
Electrophysiological correlates of episodic migraine chronification: evidence for thalamic involvement.
Article in The journal of headache and pain, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 82 citations in OpenAlex.
- The enigma of site of action of migraine preventives: no effect of metoprolol on trigeminal pain processing in patients and healthy controls.The journal of headache and pain · 2017Trial
- Topiramate modulates trigeminal pain processing in thalamo-cortical networks in humans after single dose administration.PloS one · 2017Trial
- Treatment of chronic migraine with transcutaneous stimulation of the auricular branch of the vagal nerve (auricular t-VNS): a randomized, monocentric clinical trial.The journal of headache and pain · 2015Trial
- 3T MRI thalamic segmentation reveals no macrostructural changes in interictal episodic migraine without aura compared to healthy controls.The journal of headache and pain · 2025Article
- The potential application of electrophysiological indicators in TMS treatment for MOH.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Article
- Unveiling the Role of Contingent Negative Variation (CNV) in Migraine: A Review of Electrophysiological Studies in Adults and Children.Biomedicines · 2023Review
- Characteristic oscillatory brain networks for predicting patients with chronic migraine.The journal of headache and pain · 2023Article
- Lack of Habituation in Migraine Patients Based on High-Density EEG Analysis Using the Steady State of Visual Evoked Potential.Entropy (Basel, Switzerland) · 2022Article
- Multimodal Long-Term Predictors of Outcome in Out of Hospital Cardiac Arrest Patients Treated with Targeted Temperature Management at 36 °C.Journal of clinical medicine · 2021Article
- Role of High Frequency Oscillations of Somatosensory Evoked Potentials in Deciphering Pathophysiology of Migraine.Journal of neurosciences in rural practice · 2021Article
- Migraine Is More Than Just Headache: Is the Link to Chronic Fatigue and Mood Disorders Simply Due to Shared Biological Systems?Frontiers in human neuroscience · 2021Review
- Haemodynamic activity characterization of resting state networks by fractal analysis and thalamocortical morphofunctional integrity in chronic migraine.The journal of headache and pain · 2020Article
- From transformation to chronification of migraine: pathophysiological and clinical aspects.The journal of headache and pain · 2020Review
- Short-latency afferent inhibition and somato-sensory evoked potentials during the migraine cycle: surrogate markers of a cycling cholinergic thalamo-cortical drive?The journal of headache and pain · 2020Article
- Cortical pain processing in migraine.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Beta-Blockers for Migraine Prevention: a Review Article.Current treatment options in neurology · 2019Review
- Neurophysiology of migraine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Animal Models of Chronic Migraine.Current pain and headache reports · 2018Review
- Anodal transcranial direct current stimulation over the left temporal pole restores normal visual evoked potential habituation in interictal migraineurs.The journal of headache and pain · 2017Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpisodic migraine is characterized by decreased high-frequency somatosensory oscillations (HFOs), reflecting thalamo-cortical activity, and deficient habituation of low-frequency (LF-) somatosensory evoked potentials (SSEPs) to repetitive sensory stimulation between attacks. Here, we study conventional LF-SSEPs and HFOs in episodic migraineurs who developed chronic migraine (CM).
methodsThirty-four episodic (15 interictally [MOii], 19 ictally [MOi]) and 19 CM patients underwent right median nerve SSEPs. The patient groups were compared to a group of 20 healthy volunteers (HV) of comparable age and gender distribution. We measured the N20-P25 LF-SSEP 1st amplitude block and habituation, and, after applying a band-pass filter (450-750 Hz), maximal peak-to-peak latency and the amplitudes of the early and late HFOs.
resultsReduced early HFOs, lower 1st block LF-SSEPs and deficient habituation characterize MOii. Initially higher SSEP amplitudes and late normal habituation characterize both CM and MOi patients. After the digital filtration, both patient groups showed shortened latency peaks and normalization of early HFO amplitudes with increased late HFOs. When data of MO and CM patients were combined, the monthly number of days with headache negatively correlated with the LF-SSEP slope (r = -0.385, p = 0.006), which in turn negatively correlated with the 1st amplitude block (r = 0.568, p < 0.001).
conclusionsOur results show abnormalities in chronic migraine that are also reported during attacks in episodic migraineurs, namely early response sensitization and late habituation. The HFO analysis suggests that this sensory sensitization may be explained by an increase in the strength of the connections between the thalamus and cortex compared to episodic migraine between attacks. Whether this electro-functional behaviour is primary or secondary to daily headache, thus reflecting an electrophysiological fingerprint of the somatosensory system central sensitization process, remains to be determined.
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