ArticleInfection and immunity1990
Protective immunization against experimental Bacteroides (Porphyromonas) gingivalis infection.
Article in Infection and immunity, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 69 citations in OpenAlex.
- Immunization with Porphyromonas gingivalis capsular polysaccharide prevents P. gingivalis-elicited oral bone loss in a murine model.Infection and immunity · 2003Article
- Effect of Fusobacterium nucleatum on the T and B cell responses to Porphyromonas gingivalis in a mouse model.Clinical and experimental immunology · 2002Article
- B-Cell deficiency predisposes mice to disseminating anaerobic infections: protection by passive antibody transfer.Infection and immunity · 2000Article
- RgpA-Kgp peptide-based immunogens provide protection against Porphyromonas gingivalis challenge in a murine lesion model.Infection and immunity · 2000Article
- Lack of humoral immune protection against Treponema denticola virulence in a murine model.Infection and immunity · 1999Article
- Inhibition of osteoblastic cell differentiation by lipopolysaccharide extract from Porphyromonas gingivalis.Infection and immunity · 1999Article
- In vivo induction of apoptosis and immune responses in mice by administration of lipopolysaccharide from Porphyromonas gingivalis.Infection and immunity · 1996Article
- Immunization with outer-membrane protein(s) of Bacteroides fragilis: an experimental study in mice.World journal of microbiology & biotechnology · 1994Article
- Pathogenesis of periodontitis: a major arginine-specific cysteine proteinase from Porphyromonas gingivalis induces vascular permeability enhancement through activation of the kallikrein/kinin pathway.The Journal of clinical investigation · 1994Article
- Systemic and mucosal immune responses in mice orally immunized with avirulent Salmonella typhimurium expressing a cloned Porphyromonas gingivalis hemagglutinin.Infection and immunity · 1994Article
- Immunization against Porphyromonas gingivalis inhibits progression of experimental periodontitis in nonhuman primates.Infection and immunity · 1994Article
- Serum immunoglobulin G antibody to Porphyromonas gingivalis in rapidly progressive periodontitis: titer, avidity, and subclass distribution.Infection and immunity · 1992Article
- Porphyromonas gingivalis virulence in mice: induction of immunity to bacterial components.Infection and immunity · 1992Article
- Influence of immunization on Porphyromonas gingivalis colonization and invasion in the mouse chamber model.Infection and immunity · 1992Article
- Experimental Porphyromonas gingivalis infection in nonimmune athymic BALB/c mice.Infection and immunity · 1991Article
- Effects of immunization with Porphyromonas gingivalis and Prevotella intermedia on progression of ligature-induced periodontitis in the nonhuman primate Macaca fascicularis.Infection and immunity · 1991Article
- A novel mouse model to study the virulence of and host response to Porphyromonas (Bacteroides) gingivalis.Infection and immunity · 1991Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The effects of immunization in modulating the pathogenesis of Bacteroides (Porphyromonas) gingivalis infection in a murine model system were examined. BALB/c mice were immunized by intraperitoneal injection with B. gingivalis ATCC 53977 (one injection per week for 3 weeks), or with a lithium diiodosalicylate (LIS) extract (one injection per week for 3 weeks), or with lipopolysaccharide (LPS; one intravenous or intraperitoneal injection) from this same strain. Two weeks after the final immunization, the mice were challenged by subcutaneous injection of B. gingivalis ATCC 53977. Mice immunized with bacteria had no secondary lesions and no septicemia, whereas mice immunized with LIS extract had few secondary lesions and no septicemia. Mice immunized with LPS and nonimmunized mice demonstrated secondary abdominal lesions and septicemia after challenge. Bacterial cells and LIS extract, but not LPS, induced serum antibody and antigen reactive lymphocytes, as measured by enzyme-linked immunosorbent assay, immunoblot, Western immunoblot transfer, and in vitro lymphoproliferative responses. The present study suggests that immunization with a LIS extract or whole cells may induce a protective response against experimental B. gingivalis infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.