ArticleJACC. Heart failure2013
Prostanoids but not oral therapies improve right ventricular function in pulmonary arterial hypertension.
Article in JACC. Heart failure, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- A 2-Decade Cardiac Magnetic Resonance Imaging Journey in Heritable Pulmonary Arterial Hypertension: Reversal With Sotatercept.JACC. Case reports · 2025Article
- Navigating women with congenital heart disease during pregnancy: Management strategies and future directions.World journal of cardiology · 2025Review
- Cardiovascular-obstetric state-of-the-art review: pulmonary hypertension in pregnancy.Singapore medical journal · 2025Review
- How a Most Unlikely Drug Changed the Outcome of Pulmonary Arterial Hypertension.Pulmonary circulation · 2025Review
- When pulmonary arterial hypertension and pregnancy meet: a multidisciplinary clinical experts review.Archives of gynecology and obstetrics · 2024Review
- Macitentan in the Young-Mid-term Outcomes of Patients with Pulmonary Hypertensive Vascular Disease treated in a Pediatric Tertiary Care Center.Paediatric drugs · 2023Article
- Hemodynamic indices in pulmonary hypertension: a narrative review.Cardiovascular diagnosis and therapy · 2022Review
- Management of pregnant patients with pulmonary arterial hypertension.Frontiers in cardiovascular medicine · 2022Review
- Pulmonary Hypertension in Pregnancy: A Review.Medicina (Kaunas, Lithuania) · 2021Review
- Cellular sources of interleukin-6 and associations with clinical phenotypes and outcomes in pulmonary arterial hypertension.The European respiratory journal · 2020Article
- Article
- Autonomic Nervous System in Pulmonary Arterial Hypertension: Time to Rest and Digest.Circulation · 2018Article
- The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension.Frontiers in cardiovascular medicine · 2018Review
- Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- End-Tidal Carbon Dioxide as a Prognostic Feature in Pulmonary Arterial Hypertension.Annals of the American Thoracic Society · 2017Article
- Novel putative pharmacological therapies to protect the right ventricle in pulmonary hypertension: a review of current literature.British journal of pharmacology · 2017Review
- The Critical Role of Pulmonary Arterial Compliance in Pulmonary Hypertension.Annals of the American Thoracic Society · 2016Review
- Statement on pregnancy in pulmonary hypertension from the Pulmonary Vascular Research Institute.Pulmonary circulation · 2015Article
- Use of pulmonary arterial hypertension-approved therapy in the treatment of non-group 1 pulmonary hypertension at US referral centers.Pulmonary circulation · 2015Article
- Effect of acute arteriolar vasodilation on capacitance and resistance in pulmonary arterial hypertension.Chest · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThis study hypothesized that right ventricular stroke work index (RVSWI) and pulmonary capacitance (PC) would increase after treatment for pulmonary arterial hypertension (PAH) and that prostanoids would have a stronger effect than oral therapy.
backgroundRight ventricular (RV) function is a major determinant of outcome in patients with PAH. Little is known about the response of RV function or its hemodynamic determinants to PAH-specific therapy.
methodsWe reviewed hemodynamic and health data on 58 patients from an institutional registry and analyzed changes in hemodynamic status between diagnostic and first repeat catheterization after initiation of therapy for PAH.
resultsThe RVSWI and PC increased significantly after therapy (p = 0.007 and p = 0.02, respectively). Improvement in RV function was limited to patients treated with prostanoid-only therapy (p = 0.04); no improvement was found in patients treated with oral therapy (p = 0.25). Patients with the poorest baseline RV function (lowest tertile) had the greatest improvement post-therapy (p = 0.005 and p < 0.001 vs. middle and highest tertiles). The major determinant of RVSWI was change in stroke volume (r(s) = 0.54, p < 0.001), indicating RVSWI is an accurate reflection of RV function.
conclusionsRight ventricular function improves after therapy with regimens including prostanoids but not oral-only regimens. Patients with the least compensated RV function at diagnosis might derive the most benefit from therapy. Larger studies are needed to determine whether changes in RVSWI after therapy are associated with outcomes.
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