ArticlePulmonary circulation2013
Schistosomiasis causes remodeling of pulmonary vessels in the lung in a heterogeneous localized manner: Detailed study.
Article in Pulmonary circulation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Clinical and hemodynamic evaluation of schistosomiasis-associated pulmonary arterial hypertension from Egyptian pulmonary hypertension centers: epidemiology, risk factors, and survival determinants.Scientific reports · 2026Article
- IL-6 and TGF-β1 as biomarkers of schistosomiasis-associated pulmonary hypertension in a murine model.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Article
- Global Landscape of Infection-Induced Pulmonary Hypertension.Infectious disease reports · 2025Review
- Efficacy of Arterial Embolization prior to Pancreaticoduodenectomy for Pancreatic Arteriovenous Malformation: A Case Report.Surgical case reports · 2025Article
- ExperimentalPulmonary circulation · 2024Article
- Experimental Schistosoma japonicum-induced pulmonary hypertension.PLoS neglected tropical diseases · 2022Article
- From acute SARS-CoV-2 infection to pulmonary hypertension.Frontiers in physiology · 2022Review
- A Case of Pulmonary Nodular Schistosomiasis.Tanaffos · 2022Article
- Schistosome-Associated Pulmonary Arterial Hypertension: A Review Emphasizing Pathogenesis.Frontiers in cardiovascular medicine · 2021Review
- Pulmonary hypertension: From an orphan disease to a global epidemic.Global cardiology science & practice · 2020Review
- Schistosomiasis Pulmonary Arterial Hypertension.Frontiers in immunology · 2020Review
- Schistosome infection and its effect on pulmonary circulation.Global cardiology science & practice · 2019Review
- Infection in pulmonary vascular diseases: Would another consortium really be the way to go?Global cardiology science & practice · 2019Article
- Role of extracellular matrix in the pathogenesis of pulmonary arterial hypertension.American journal of physiology. Heart and circulatory physiology · 2018Review
- Enhanced inflammatory cell profiles in schistosomiasis-induced pulmonary vascular remodeling.Pulmonary circulation · 2017Article
- Non-infectious Pulmonary Diseases and HIV.Current HIV/AIDS reports · 2016Review
- Schistosomiasis-associated pulmonary hypertension.Pulmonary circulation · 2014Review
- Animal Models of Pulmonary Hypertension: Matching Disease Mechanisms to Etiology of the Human Disease.Journal of pulmonary & respiratory medicine · 2014Article
- Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Schistosomiasis and pulmonary arterial hypertension.Annals of thoracic medicine · 2014Article
- Pathological changes in pulmonary circulation in carbon tetrachloride (CCl4)-induced cirrhotic mice.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
Schistosomiasis is a global parasitic disease with high impact on public health in tropical areas. Schistosomiasis is a well-described cause of pulmonary arterial hypertension (PAH). The exact pathogenesis is still unclear, though inflammatory mechanisms are suspected. Another unknown is whether the changes in the pulmonary vasculature are generalized or localized. We studied 13 mice infected with cercariae for 12 weeks compared with 10 control mice. In our model, we observed that the liver was a target during infection and was enlarged more than two-fold after infection. However, right heart hypertrophy as measured by RV/(LV + S) ratio was not observed at this time point. Moreover, we noticed that 72% of the sampled lobes (92% of the lungs) harvested from these animals costained evidence of granulomatous changes, secondary to egg deposition. We systemically mapped the distribution of granulomatous lesions in right lung lobes (n = 43) of infected mice. We observed that the distribution of the granulomatous lesions was heterogeneous. Remodeled pulmonary vessels were seen in 26% of the lobes (46% of the lungs) and were observed only in close proximity to the granuloma. No remodeling was observed in the absence of granulomas. These findings support the view that pulmonary vascular remodeling is caused by the local presence of granulomas in PAH associated with schistosomiasis. The heterogeneous nature of the remodeling partly explains why many patients with schistosomiasis do not develop pulmonary hypertension.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.