ArticlePloS one2013
Mapping the genetic variation of regional brain volumes as explained by all common SNPs from the ADNI study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The Association Between Neighborhood Poverty and Hippocampal Volume Among Individuals at Clinical High-Risk for Psychosis: The Moderating Role of Social Engagement.Schizophrenia bulletin · 2022Article
- The effect of ApoE ε 4 on clinical and structural MRI markers in prodromal Alzheimer's disease.Quantitative imaging in medicine and surgery · 2020Article
- Heritability of Regional Brain Volumes in Large-Scale Neuroimaging and Genetic Studies.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Reliable heritability estimation using sparse regularization in ultrahigh dimensional genome-wide association studies.BMC bioinformatics · 2019Article
- Structural covariability hubs in old age.NeuroImage · 2019Article
- The structural MRI markers and cognitive decline in prodromal Alzheimer's disease: a 2-year longitudinal study.Quantitative imaging in medicine and surgery · 2018Article
- Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia.Molecular psychiatry · 2016Article
- BFLCRM: A BAYESIAN FUNCTIONAL LINEAR COX REGRESSION MODEL FOR PREDICTING TIME TO CONVERSION TO ALZHEIMER'S DISEASE.The annals of applied statistics · 2015Article
- Large-scale genomics unveil polygenic architecture of human cortical surface area.Nature communications · 2015Article
- 2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015Review
- Genetics and brain morphology.Neuropsychology review · 2015Article
- Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks.BMC genomics · 2015Article
- Predicting Alzheimer's Disease Using Combined Imaging-Whole Genome SNP Data.Journal of Alzheimer's disease : JAD · 2015Article
- Applying imaging genetics to ADHD: the promises and the challenges.Molecular neurobiology · 2014Review
- Genomics in neurological disorders.Genomics, proteomics & bioinformatics · 2014Review
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Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Typically twin studies are used to investigate the aggregate effects of genetic and environmental influences on brain phenotypic measures. Although some phenotypic measures are highly heritable in twin studies, SNPs (single nucleotide polymorphisms) identified by genome-wide association studies (GWAS) account for only a small fraction of the heritability of these measures. We mapped the genetic variation (the proportion of phenotypic variance explained by variation among SNPs) of volumes of pre-defined regions across the whole brain, as explained by 512,905 SNPs genotyped on 747 adult participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI). We found that 85% of the variance of intracranial volume (ICV) (p = 0.04) was explained by considering all SNPs simultaneously, and after adjusting for ICV, total grey matter (GM) and white matter (WM) volumes had genetic variation estimates near zero (p = 0.5). We found varying estimates of genetic variation across 93 non-overlapping regions, with asymmetry in estimates between the left and right cerebral hemispheres. Several regions reported in previous studies to be related to Alzheimer's disease progression were estimated to have a large proportion of volumetric variance explained by the SNPs.
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