SynthesisPloS one2013
Hypoxia-inducible factor-1α polymorphisms and risk of cancer metastasis: a meta-analysis.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Genetic variability ofRadiology and oncology · 2025Article
- Comparison of HIF-1α and survivin levels in patients with diabetes and retinopathy of varying severity.Arquivos brasileiros de oftalmologia · 2024Article
- Genome-Wide Analysis Reveals Hypoxic Microenvironment Is Associated With Immunosuppression in Poor Survival of Stage II/III Colorectal Cancer Patients.Frontiers in medicine · 2021Article
- The Effects of Anesthetics on Recurrence and Metastasis of Cancer, and Clinical Implications.World journal of oncology · 2017Review
- HIF1A gene polymorphisms and human diseases: Graphical review of 97 association studies.Genes, chromosomes & cancer · 2017Review
- Survivin contributes to the progression of diabetic retinopathy through HIF-1α pathway.International journal of clinical and experimental pathology · 2015Article
- HIF-1 alpha overexpression correlates with poor overall survival and disease-free survival in gastric cancer patients post-gastrectomy.PloS one · 2014Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHIF-1α is a major regulator in tumor progression and metastasis which responds to hypoxia. Many studies have demonstrated that hypoxia-inducible factor1-α (HIF-1α) polymorphisms are significantly associated with cancer metastasis, but the results are inconsistent. We conducted a comprehensive meta-analysis to estimate the associations between HIF-1α C1772 T polymorphism and cancer metastasis.
methodsComprehensive searches were conducted on PubMed and EMBASE database. Fifteen studies were included in the meta-analysis. We used the OR and 95%CI to assess the associations between HIF-1α C1772T polymorphism and cancer metastasis. Heterogeneity and publication bias were also assessed by Q test, I (2), and funnel plot.
resultsTotally, fifteen studies including 1239 cases with metastasis-positive (M+) and 2711 cases with metastasis-negative (M-) were performed in this meta-analysis. The results showed that HIF-1a C1772T polymorphism was associated with the increased risk of cancer metastasis (T allele vs. C allele, OR = 1.36, 95% CI = 1.12-1.64; TT+ TC vs. CC, OR = 1.39, 95% CI = 1.13-1.71; TT vs. TC+ CC, OR = 1.93, 95% CI = 0.86-4.36). In the subgroup analyses, the significant associations remained significant among Asians, Caucasians and other cancers in the dominant model. Publication bias was not observed in the analysis.
conclusionsOur results indicate that the HIF-1αC1772T polymorphism T allele may increase the risk of cancer metastasis, which might be a potential risk factor of cancer progress.
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