ArticleCellular and molecular bioengineering2012
Mechanical strain controls endothelial patterning during angiogenic sprouting.
Article in Cellular and molecular bioengineering, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 35 citations in OpenAlex.
- Active Microrheology Reveals Distinct ECM Mechanical Signatures Induced by Stromal Cells of Different Tissue Origins during Vascular Morphogenesis.ACS biomaterials science & engineering · 2026Article
- Fibrin-Based Hydrogels with Reactive Amphiphilic Copolymers for Mechanical Adjustments Allow for Capillary Formation in 2D and 3D Environments.Gels (Basel, Switzerland) · 2024Article
- Fixators dynamization for delayed union and non-union of femur and tibial fractures: a review of techniques, timing and influence factors.Journal of orthopaedic surgery and research · 2023Review
- Stiffened fibre-like microenvironment based on patterned equidistant micropillars directs chondrocyte hypertrophy.Materials today. Bio · 2023Article
- On the role of mechanical signals on sprouting angiogenesis through computer modeling approaches.Biomechanics and modeling in mechanobiology · 2022Review
- Mechanical Aspects of Angiogenesis.Cancers · 2021Review
- Cell-mediated matrix stiffening accompanies capillary morphogenesis in ultra-soft amorphous hydrogels.Biomaterials · 2020Article
- Biofabrication of thick vascularized neo-pedicle flaps for reconstructive surgery.Translational research : the journal of laboratory and clinical medicine · 2019Review
- Tissue Engineering the Vascular Tree.Tissue engineering. Part B, Reviews · 2017Review
- Sculpting the blank slate: how fibrin's support of vascularization can inspire biomaterial design.Acta biomaterialia · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cyclic strain is known to affect endothelial cell phenotype, but its effects on neovascular pattern formation remain poorly understood. To examine how cyclic strain affects angiogenesis, we designed a stretchable, polydimethylsiloxane (PDMS)-based multi-well system that supports a 3D cell culture model of angiogenesis, consisting of endothelial cells coated onto microcarrier beads embedded in a fibrin gel with a supporting monolayer of smooth muscle cells atop the gel. Calibration of the integrated system showed a linear relationship between applied strain and strain within the fibrin gel. Capillaries formed in unstrained conditions grew radially outward, while 3D constructs subjected to 10% cyclic strain at 0.7 Hz sprouted in a direction parallel to the applied strain. Removal of the tissue from the strain stimulus eliminated directional sprouting. To better understand this directional biasing, the strain field surrounding a microcarrier bead was modeled computationally, showing local strain anisotropy surrounding a microcarrier. Confocal reflection microscopy revealed only modest fiber alignment in regions of the gel close to microcarriers, with no evidence of alignment further away. Together, these data showed that externally applied cyclic strain can spatially pattern capillaries in a 3D culture, and suggests a means to control pattern formation in engineered tissues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.