Tapentadol hydrochloride: A novel analgesic.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.

1. Safety of Opioids in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis.Drugs & aging · 2019
   Pooled it
2. A Multicenter, Randomized, Open-Label, Active-Controlled, Parallel-Group Study Evaluating the Pharmacokinetics of Single-Dose Tapentadol Hydrochloride Intravenous Infusion and Tapentadol Hydrochloride Oral Tablets in Patients with Pain.European journal of drug metabolism and pharmacokinetics · 2025
   Trial
3. Tapentadol-induced urticarial rash in a patient with acute pancreatitis.Indian journal of pharmacology · 2026
   Article
4. Preclinical assay of the effects of lacosamide, pregabalin, and tapentadol on the rat N1 spinal somatosensory evoked potential.Pain · 2026
   Article
5. Formulation, Development, and Optimization of Fast Dissolving Tablets Containing Tapentadol Hydrochloride.Pharmaceutical nanotechnology · 2026
   Article
6. Assessment of antidiabetic, hepatoprotective, and analgesic effects of quinazolinone derivative, (E)-1-Benzoyl-3-((4- (Dimethylamino) Benzylidene) Amino)-2-(4-(Dimethylamino) Phenyl)-2,3 dihydroquinazoline-4(1h)-one, in diabetes induced mice model.PloS one · 2026
   Article
7. Combination of Tapentadol Nasal Spray and Radiotherapy for Managing Moderate-to-Severe Pain from Lytic Bone Metastasis.Annals of African medicine · 2025
   Article
8. RNA Interference Unleashed: Current Perspective of Small Interfering RNA (siRNA) Therapeutics in the Treatment of Neuropathic Pain.ACS pharmacology & translational science · 2024
   Review
9. The psychophysiology of music-based interventions and the experience of pain.Frontiers in psychology · 2024
   Review
10. Pharmacological Treatments and Therapeutic Drug Monitoring in Patients with Chronic Pain.Pharmaceutics · 2023
    Review
11. Novel Natrosol/Pectin-co-poly (acrylate) based pH-responsive polymeric carrier system for controlled delivery of Tapentadol Hydrochloride.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Article
12. Neuropathic pain: Mechanisms and therapeutic strategies.Frontiers in cell and developmental biology · 2023
    Review
13. Patient Perceptions and Potential Utility of Pharmacogenetic Testing in Chronic Pain Management and Opioid Use Disorder in the Camden Opioid Research Initiative.Pharmaceutics · 2022
    Article
14. Multimechanistic Single-Entity Combinations for Chronic Pain Control: A Narrative Review.Cureus · 2022
    Review
15. Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier.Pharmaceutics · 2021
    Review
16. Comparison between pre-emptive oral tramadol and tapentadol for attenuation of catheter-related bladder discomfort and surgical stress response in patients undergoing transurethral resection of prostate: A prospective, randomised, double-blind trial.Indian journal of anaesthesia · 2021
    Article
17. Genetics and Opioids: Towards More Appropriate Prescription in Cancer Pain.Cancers · 2020
    Review
18. Repeated Administration of Clinical Doses of Tramadol and Tapentadol Causes Hepato- and Nephrotoxic Effects in Wistar Rats.Pharmaceuticals (Basel, Switzerland) · 2020
    Article
19. Approaches and Best Practices for Managing Cancer Pain within the Constraints of the COVID-19 Pandemic in India.Indian journal of palliative care · 2020
    Article
20. Pragmatic Opioid Use in Painful Diabetic Neuropathy.European endocrinology · 2020
    Review

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

4 authors at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

Indexed as