ArticleJournal of experimental botany2013
Genome-wide identification and characterization of cadmium-responsive microRNAs and their target genes in radish (Raphanus sativus L.) roots.
Article in Journal of experimental botany, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 129 citations in OpenAlex.
- A Genome‑wide Association Study of the Grain Ionome in Rice Oryza Sativa Ssp. Japonica under Two Diverse Water Management Systems.Rice (New York, N.Y.) · 2025Article
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- Advances in epigenetic studies of plant cadmium stress.Frontiers in plant science · 2024Review
- miR397-LACs mediated cadmium stress tolerance in Arabidopsis thaliana.Plant molecular biology · 2023Article
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- Recent allopolyploidy alters Spartina microRNA expression in response to xenobiotic-induced stress.Plant molecular biology · 2023Article
- Comprehensive Genomic Survey, Evolution, and Expression Analysis of GIF Gene Family during the Development and Metal Ion Stress Responses in Soybean.Plants (Basel, Switzerland) · 2022Article
- Genome-Wide Characterization of the Aquaporin Gene Family in Radish and Functional Analysis ofFrontiers in plant science · 2022Article
- Integration of Small RNA and Degradome Sequencing Reveals the Regulatory Network of Al-Induced Programmed Cell Death in Peanut.International journal of molecular sciences · 2021Article
- Article
- MicroRNAs: Potential Targets for Developing Stress-Tolerant Crops.Life (Basel, Switzerland) · 2021Review
- MicroRNA-Mediated Responses to Cadmium Stress inPlants (Basel, Switzerland) · 2021Article
- Genome-Wide Identification and Functional Characterization of the Cation Proton Antiporter (CPA) Family Related to Salt Stress Response in Radish (International journal of molecular sciences · 2020Article
- Barley yellow dwarf virus-GAV-derived vsiRNAs are involved in the production of wheat leaf yellowing symptoms by targeting chlorophyll synthase.Virology journal · 2020Article
- Genome-wide sRNA and mRNA transcriptomic profiling insights into dynamic regulation of taproot thickening in radish (Raphanus sativus L.).BMC plant biology · 2020Article
- miRNA-mRNA Integrated Analysis Reveals Roles for miRNAs in a Typical Halophyte,Plants (Basel, Switzerland) · 2020Article
- High-throughput deep sequencing reveals the important role that microRNAs play in the salt response in sweet potato (Ipomoea batatas L.).BMC genomics · 2020Article
- Modulation of Plant and Fungal Gene Expression Upon Cd Exposure and Symbiosis in Ericoid MycorrhizalFrontiers in microbiology · 2020Article
- MicroRNA expression patterns unveil differential expression of conserved miRNAs and target genes against abiotic stress in safflower.PloS one · 2020Article
- MicroRNA-mRNA expression profiles and their potential role in cadmium stress response in Brassica napus.BMC plant biology · 2019Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) are endogenous non-coding small RNAs that play vital regulatory roles in plant growth, development, and environmental stress responses. Cadmium (Cd) is a non-essential heavy metal that is highly toxic to living organisms. To date, a number of conserved and non-conserved miRNAs have been identified to be involved in response to Cd stress in some plant species. However, the miRNA-mediated gene regulatory networks responsive to Cd stress in radish (Raphanus sativus L.) remain largely unexplored. To dissect Cd-responsive miRNAs and their targets systematically at the global level, two small RNA libraries were constructed from Cd-treated and Cd-free roots of radish seedlings. Using Solexa sequencing technology, 93 conserved and 16 non-conserved miRNAs (representing 26 miRNA families) and 28 novel miRNAs (representing 22 miRNA families) were identified. In all, 15 known and eight novel miRNA families were significantly differently regulated under Cd stress. The expression patterns of a set of Cd-responsive miRNAs were validated by quantitative real-time PCR. Based on the radish mRNA transcriptome, 18 and 71 targets for novel and known miRNA families, respectively, were identified by the degradome sequencing approach. Furthermore, a few target transcripts including phytochelatin synthase 1 (PCS1), iron transporter protein, and ABC transporter protein were involved in plant response to Cd stress. This study represents the first transcriptome-based analysis of miRNAs and their targets responsive to Cd stress in radish roots. These findings could provide valuable information for functional characterization of miRNAs and their targets in regulatory networks responsive to Cd stress in radish.
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