ArticleAmerican journal of physiology. Heart and circulatory physiology2013
Sympathetic cardiac hyperinnervation and atrial autonomic imbalance in diet-induced obesity promote cardiac arrhythmias.
Article in American journal of physiology. Heart and circulatory physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Metabolic and Inflammatory Mechanisms Driving Atrial Fibrillation.Annual review of pharmacology and toxicology · 2026Review
- Macrophage Immunometabolism in Epicardial Adipose Tissue and Obesity-Related Atrial Fibrillation.Journal of inflammation research · 2026Review
- Reply to: "Prophylactic Lymphovenous Bypass for Breast Cancer-Related Lymphedema: Research Challenges, Statistical Pitfalls, and Solutions".Annals of surgical oncology · 2025Article
- Immune cells and arrhythmias.Cardiovascular research · 2025Review
- The Prevalence of Arrhythmias, Including Premature Supraventricular and Ventricular Beats and Other Electrocardiographic Patterns, in 24-Hour Holter Monitoring in Patients with Overweight and Obesity.Life (Basel, Switzerland) · 2024Article
- Impact of Obesity on Atrial Fibrillation Pathogenesis and Treatment Options.Journal of the American Heart Association · 2024Review
- Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance.Cardiovascular research · 2023Review
- The autonomic nervous system in atrial fibrillation-pathophysiology and non-invasive assessment.Frontiers in cardiovascular medicine · 2023Review
- Obesity and sudden cardiac death: Prevalence, pathogenesis, prevention and intervention.Frontiers in cell and developmental biology · 2022Review
- Mechanisms of Chronic Metabolic Stress in Arrhythmias.Antioxidants (Basel, Switzerland) · 2020Review
- High prevalence of hyperlipidaemia in patients with AV re-entry tachycardia and AV nodal re-entry tachycardia.Scientific reports · 2019Article
- Body Mass Index and Sudden Cardiac Death in Japanese Patients After Acute Myocardial Infarction: Data From the JCAD Study and HIJAMI-II Registry.Journal of the American Heart Association · 2018Article
- The Impact of Obesity on the Cardiovascular System.Journal of diabetes research · 2018Review
- CaMKII Activation Promotes Cardiac Electrical Remodeling and Increases the Susceptibility to Arrhythmia Induction in High-fat Diet-Fed Mice With Hyperlipidemia Conditions.Journal of cardiovascular pharmacology · 2017Article
- Molecular Mechanisms of Sympathetic Remodeling and Arrhythmias.Circulation. Arrhythmia and electrophysiology · 2016Review
- High fat diet induced alterations of atrial electrical activities in mice.American journal of cardiovascular disease · 2016Article
- Growth and Obesity Among Older Single Ventricle Patients Presenting for Fontan Conversion.World journal for pediatric & congenital heart surgery · 2015Article
- Xyloketal B attenuates atherosclerotic plaque formation and endothelial dysfunction in apolipoprotein e deficient mice.Marine drugs · 2015Article
- Leptin stimulates sympathetic axon outgrowth.Neuroscience letters · 2014Article
- A Review on Role of Yoga in the Management of Patients with Cardiac Arrhythmias.International journal of yogaReview
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Obesity increases the risk of arrhythmias and sudden cardiac death, but the mechanisms are unknown. This study tested the hypothesis that obesity-induced cardiac sympathetic outgrowth and hyperinnervation promotes the development of arrhythmic events. Male Sprague-Dawley rats (250-275 g), fed a high-fat diet (33% kcal/fat), diverged into obesity-resistant (OR) and obesity-prone (OP) groups and were compared with rats fed normal chow (13% kcal/fat; CON). In vitro experiments showed that both OR and OP rats exhibited hyperinnervation of the heart and high sympathetic outgrowth compared with CON rats, even though OR rats are not obese. Despite the hyperinnervation and outgrowth, we showed that, in vivo, OR rats were less susceptible to arrhythmic events after an intravenous epinephrine challenge compared with OP rats. On examining total and stimulus-evoked neurotransmitter levels in an ex vivo system, we demonstrate that atrial acetylcholine content and release were attenuated in OP compared with OR and CON groups. OP rats also expressed elevated atrial norepinephrine content, while norepinephrine release was suppressed. These findings suggest that the consumption of a high-fat diet, even in the absence of overt obesity, stimulates sympathetic outgrowth and hyperinnervation of the heart. However, normalized cardiac parasympathetic nervous system control may protect the heart from arrhythmic events.
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