ReviewAmerican journal of physiology. Heart and circulatory physiology2013
Recording sympathetic nerve activity chronically in rats: surgery techniques, assessment of nerve activity, and quantification.
Review in American journal of physiology. Heart and circulatory physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Central nervous system mechanisms of salt-sensitive hypertension.Physiological reviews · 2025Review
- Rhythmic firing of neurons in the medulla of conscious freely behaving rats: rhythmic coupling with baroreceptor input.Pflugers Archiv : European journal of physiology · 2023Article
- Fatty acid amide hydrolase activity in the dorsal periaqueductal gray attenuates neuropathic pain and associated dysautonomia.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Regional Differences in Sympathetic Nerve Activity Are Generated by Multiple Arterial Baroreflex Loops Arranged in Parallel.Frontiers in physiology · 2022Review
- Augmented Respiratory-Sympathetic Coupling and Hemodynamic Response to Acute Mild Hypoxia in Female Rodents With Chronic Kidney Disease.Frontiers in physiology · 2021Article
- Printable microscale interfaces for long-term peripheral nerve mapping and precision control.Nature communications · 2020Article
- Renal sympathetic nerve activity regulates cardiovascular energy expenditure in rats fed high salt.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Stretchable Low Impedance Electrodes for Bioelectronic Recording from Small Peripheral Nerves.Scientific reports · 2019Article
- Autonomic nerves and circadian control of renal function.Autonomic neuroscience : basic & clinical · 2019Review
- Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases.GeroScience · 2019Review
- Chronic intermittent hypoxia-mediated renal sympathetic nerve activation in hypertension and cardiovascular disease.Scientific reports · 2018Article
- Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats.Journal of visualized experiments : JoVE · 2018Article
- Modulation of renal sympathetic innervation: recent insights beyond blood pressure control.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Review
- Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.Journal of visualized experiments : JoVE · 2018Article
- Electrical stimulation of renal nerves for modulating urine glucose excretion in rats.Bioelectronic medicine · 2018Article
- Increased activity of the orexin system in the paraventricular nucleus contributes to salt-sensitive hypertension.American journal of physiology. Heart and circulatory physiology · 2017Article
- Chronic interfacing with the autonomic nervous system using carbon nanotube (CNT) yarn electrodes.Scientific reports · 2017Article
- Recording sympathetic nerve activity in conscious humans and other mammals: guidelines and the road to standardization.American journal of physiology. Heart and circulatory physiology · 2017Review
- Deciphering the Neural Control of Sympathetic Nerve Activity: Status Report and Directions for Future Research.Frontiers in neuroscience · 2017Review
- A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication.Nature communications · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The sympathetic nervous system plays a pivotal role in homeostasis through its direct innervation and functional impact on a variety of end organs. In rats, a number of methods are available to assess sympathetic nervous system function. Traditionally, direct recording of sympathetic nerve activity (SNA) has been restricted to acute, anesthetized preparations or conscious animals within a few days after electrode implantation. However, these approaches provide short-term data in studies designed to investigate changes in SNA during chronic disease states. Over the last several years, chronic SNA recording has been pioneered in rabbits and more recently in rats. The purpose of this article is to provide insights and a "how to" guide for chronic SNA recordings in rats based on experiences from two independent laboratories. We will present common methodologies used to chronically record SNA, characteristics and methods to distinguish sympathetic bursts versus electrical artifacts (and provide corresponding audio clips when available), and provide suggestions for analysis and presentation of data. In many instances, these same guidelines are applicable to acute SNA recordings. Using the surgical approaches described herein, both laboratories have been able to chronically record SNA in >50% of rats for a duration >3 wk. The ability to record SNA over the time course of several weeks will, undoubtedly, greatly impact the field of autonomic and cardiovascular physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.