ArticleAmerican journal of physiology. Heart and circulatory physiology2013
Attenuated muscle metaboreflex-induced increases in cardiac function in hypertension.
Article in American journal of physiology. Heart and circulatory physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Characterization of a novel ovine model of hypertensive heart failure with preserved ejection fraction.American journal of physiology. Heart and circulatory physiology · 2024Article
- Guidelines for animal exercise and training protocols for cardiovascular studies.American journal of physiology. Heart and circulatory physiology · 2020Review
- Clinical safety of blood flow-restricted training? A comprehensive review of altered muscle metaboreflex in cardiovascular disease during ischemic exercise.American journal of physiology. Heart and circulatory physiology · 2020Review
- Muscle metaboreflex-induced central blood volume mobilization in heart failure.American journal of physiology. Heart and circulatory physiology · 2019Article
- Neural Control of Cardiovascular Function During Exercise in Hypertension.Frontiers in physiology · 2018Review
- Inflammatory and oxidative stress‑associated factors in chronic intermittent hypoxia in Chinese patients, rats, lymphocytes and endotheliocytes.Molecular medicine reports · 2017Article
- Mineralocorticoids: the secret of muscle reflex dysfunction in hypertension?American journal of physiology. Heart and circulatory physiology · 2017Article
- Role of endothelial nitric oxide in control of peripheral vascular conductance during muscle metaboreflex activation.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Exaggerated coronary vasoconstriction limits muscle metaboreflex-induced increases in ventricular performance in hypertension.American journal of physiology. Heart and circulatory physiology · 2017Article
- Blood flow restriction training and the exercise pressor reflex: a call for concern.American journal of physiology. Heart and circulatory physiology · 2015Review
- Attenuated muscle metaboreflex-induced pressor response during postexercise muscle ischemia in renovascular hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Functional sympatholysis in hypertension.Autonomic neuroscience : basic & clinical · 2015Review
- Muscle mechanoreflex overactivity in hypertension: a role for centrally-derived nitric oxide.Autonomic neuroscience : basic & clinical · 2015Review
- Muscle metaboreflex activation during dynamic exercise evokes epinephrine release resulting in β2-mediated vasodilation.American journal of physiology. Heart and circulatory physiology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Sympathoactivation may be excessive during exercise in subjects with hypertension, leading to increased susceptibility to adverse cardiovascular events, including arrhythmias, infarction, stroke, and sudden cardiac death. The muscle metaboreflex is a powerful cardiovascular reflex capable of eliciting marked increases in sympathetic activity during exercise. We used conscious, chronically instrumented dogs trained to run on a motor-driven treadmill to investigate the effects of hypertension on the mechanisms of the muscle metaboreflex. Experiments were performed before and 30.9 ± 4.2 days after induction of hypertension, which was induced via partial, unilateral renal artery occlusion. After induction of hypertension, resting mean arterial pressure was significantly elevated from 98.2 ± 2.6 to 141.9 ± 7.4 mmHg. The hypertension was caused by elevated total peripheral resistance. Although cardiac output was not significantly different at rest or during exercise after induction of hypertension, the rise in cardiac output with muscle metaboreflex activation was significantly reduced in hypertension. Metaboreflex-induced increases in left ventricular function were also depressed. These attenuated cardiac responses caused a smaller metaboreflex-induced rise in mean arterial pressure. We conclude that the ability of the muscle metaboreflex to elicit increases in cardiac function is impaired in hypertension, which may contribute to exercise intolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.