Observational studyMultiple sclerosis (Houndmills, Basingstoke, England)2013
Observational case-control study of the prevalence of chronic cerebrospinal venous insufficiency in multiple sclerosis: results from the CoSMo study.
Observational study in Multiple sclerosis (Houndmills, Basingstoke, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Percutaneous transluminal angioplasty for treatment of chronic cerebrospinal venous insufficiency (CCSVI) in people with multiple sclerosis.The Cochrane database of systematic reviews · 2019Pooled it
- Developmental venous anomalies in patients with multiple sclerosis: is that a coincidence or an ancillary finding?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- The Central Vein: FLAIR Signal Abnormalities Associated with Developmental Venous Anomalies in Patients with Multiple Sclerosis.AJNR. American journal of neuroradiology · 2018Article
- Chronic Cerebro-Spinal Venous Insufficiency in Multiple Sclerosis: Is It the End?Vascular specialist international · 2018Article
- Four-dimensional flow magnetic resonance imaging and ultrasound assessment of cerebrospinal venous flow in multiple sclerosis patients and controls.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Centralized and Local Color Doppler Ultrasound Reading Agreement for Diagnosis of the Chronic Cerebrospinal Venous Insufficiency in Patients with Multiple Sclerosis.Current neurovascular research · 2017Article
- Why Current Doppler Ultrasound Methodology Is Inaccurate in Assessing Cerebral Venous Return: The Alternative of the Ultrasonic Jugular Venous Pulse.Behavioural neurology · 2016Review
- Autonomic Dysregulation in Multiple Sclerosis.International journal of molecular sciences · 2015Review
- An anatomy-based lumped parameter model of cerebrospinal venous circulation: can an extracranial anatomical change impact intracranial hemodynamics?BMC neurology · 2015Article
- "Liberation treatment" for chronic cerebrospinal venous insufficiency in multiple sclerosis: the truth will set you free.Brain and behavior · 2015Review
- Chronic cerebrospinal venous insufficiency: the end of "the Big Idea"?Brain and behavior · 2015Article
- Chronic cerebrospinal venous insufficiency in patients with Ménière's disease.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2015Article
- Validity of the diagnostic criteria for chronic cerebrospinal venous insufficiency and association with multiple sclerosis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2014Article
- Cerebrospinal Venous Outflow in Multiple Sclerosis Patients versus Fatigue and/or Depression.Interventional neurology · 2014Article
- Thrombotic processes in multiple sclerosis as manifestation of innate immune activation.Frontiers in neurology · 2014Review
- Is there any relation between chronic cerebrospinal venous insufficiency and multiple sclerosis? - a critical review.Polish journal of radiology · 2014Review
- Evaluation of hemodynamic properties of cerebral venous drainage in patients with multiple sclerosis: a case-control study.Polish journal of radiology · 2014Article
- Potential involvement of the extracranial venous system in central nervous system disorders and aging.BMC medicine · 2013Review
- Multiple sclerosis: CCSVI deconstructed and discarded.Nature reviews. Neurology · 2013Article
- Cerebral venous hemodynamic abnormalities in episodic and chronic migraine.Functional neurologyArticle
Corrections and comments
- Commented on by
Authors and funding
13 authors at 10 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic cerebrospinal venous insufficiency (CCSVI) has been proposed as a possible cause of multiple sclerosis (MS).
objectivesThe CoSMo study evaluated the association between CCSVI and MS.
methodsThe primary end-point of this multicentric, case-control study was to compare the prevalence of CCSVI between patients with MS, patients with other neurodegenerative diseases (ONDs) and healthy controls (HCs). Color-coded duplex sonography was performed by a sonologist and the images were sent to one of three central sonologists for a second reading. Agreement between local and central sonologists or, in case of disagreement, the predominant judgment among the three central readers, was required for a diagnosis of CCSVI. All readings, data collection and analysis were blinded.
resultsThe study involved 35 MS centers across Italy and included 1874 subjects aged 18-55. 1767 (94%) were evaluable: 1165 MS patients, 226 patients with ONDs and 376 HCs. CCSVI prevalence was 3.26%, 3.10% and 2.13% for the MS, OND and HC groups, respectively. No significant difference in CCSVI prevalence was found amongst the three cohorts (MS versus HC, OR = 1.55, 95%CI = 0.72-3.36, p = 0.30; OND versus HC, OR = 1.47, 95%CI = 0.53-4.11, p = 0.46; MS versus OND, OR = 1.05, 95%CI = 0.47-2.39, p = 0.99). High negative and low positive agreement was found between the local and centralized readers.
conclusionsCCSVI is not associated with MS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.