ArticleThe Plant cell2013
Tissue-specific profiling reveals transcriptome alterations in Arabidopsis mutants lacking morphological phenotypes.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Genome-Wide Identification and In Silico Analysis of ZF-HD Transcription Factor Genes inGenes · 2022Article
- Potassium transporter TRH1/KUP4 contributes to distinct auxin-mediated root system architecture responses.Plant physiology · 2022Article
- Gene expression underlying floral epidermal specialization in Aristolochia fimbriata (Aristolochiaceae).Annals of botany · 2021Article
- Zinc Finger-Homeodomain Transcriptional Factors (ZF-HDs) in Wheat (Plants (Basel, Switzerland) · 2021Article
- GLABRA2 Regulates Actin Bundling Protein VILLIN1 in Root Hair Growth in Response to Osmotic Stress.Plant physiology · 2020Article
- Contribution of Root Hair Development to Sulfate Uptake inPlants (Basel, Switzerland) · 2019Article
- Molecular and physiological responses to titanium dioxide and cerium oxide nanoparticles in Arabidopsis.Environmental toxicology and chemistry · 2017Article
- Trichome patterning control involves TTG1 interaction with SPL transcription factors.Plant molecular biology · 2016Article
- Hormone activities and the cell cycle machinery in immunity-triggered growth inhibition.Journal of experimental botany · 2015Review
- Molecular phenotyping of plant single cell-types enhances forward genetic analyses.Frontiers in plant science · 2015Article
- Re-analysis of RNA-seq transcriptome data reveals new aspects of gene activity in Arabidopsis root hairs.Frontiers in plant science · 2015Article
- Arabidopsis TTG2 regulates TRY expression through enhancement of activator complex-triggered activation.The Plant cell · 2014Article
- Regulation of epidermal cell fate in Arabidopsis roots: the importance of multiple feedback loops.Frontiers in plant science · 2014Review
- Root hairs.The arabidopsis book · 2014Article
- Regulation of root hair cell differentiation by R3 MYB transcription factors in tomato and Arabidopsis.Frontiers in plant science · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Traditional genetic analysis relies on mutants with observable phenotypes. Mutants lacking visible abnormalities may nevertheless exhibit molecular differences useful for defining gene function. To examine this, we analyzed tissue-specific transcript profiles from Arabidopsis thaliana transcription factor gene mutants with known roles in root epidermis development, but lacking a single-gene mutant phenotype due to genetic redundancy. We discovered substantial transcriptional changes in each mutant, preferentially affecting root epidermal genes in a manner consistent with the known double mutant effects. Furthermore, comparing transcript profiles of single and double mutants, we observed remarkable variation in the sensitivity of target genes to the loss of one or both paralogous genes, including preferential effects on specific branches of the epidermal gene network, likely reflecting the pathways of paralog subfunctionalization during evolution. In addition, we analyzed the root epidermal transcriptome of the transparent testa glabra2 mutant to clarify its role in the network. These findings provide insight into the molecular basis of genetic redundancy and duplicate gene diversification at the level of a specific gene regulatory network, and they demonstrate the usefulness of tissue-specific transcript profiling to define gene function in mutants lacking informative visible changes in phenotype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.