ArticleApplied and environmental microbiology2013
Insights into the mode of action of benzyl isothiocyanate on Campylobacter jejuni.
Article in Applied and environmental microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- A 14-Day Double-Blind, Randomized, Controlled Crossover Intervention Study with Anti-Bacterial Benzyl Isothiocyanate from Nasturtium (Nutrients · 2024Trial
- Poultry handling-related stress alters membrane composition, extracellular vesicle production, survival, and virulence inApplied and environmental microbiology · 2026Article
- The Potential of Plant Secondary Metabolites as Bread Mould Inhibitors: Exploring Their Individual and Combined Antifungal Effect.Foods (Basel, Switzerland) · 2025Article
- Transcriptomic and Molecular Docking Analysis Reveal Virulence Gene Regulation-Mediated Antibacterial Effects of Benzyl Isothiocyanate Against Staphylococcus aureus.Applied biochemistry and biotechnology · 2024Article
- Antimalarial Activity of Aqueous Extracts of Nasturtium (Molecules (Basel, Switzerland) · 2024Article
- Benzyl isothiocyanate improves the prognosis ofFrontiers in microbiology · 2023Article
- Glucosinolates, a natural chemical arsenal: More to tell than the myrosinase story.Frontiers in microbiology · 2023Review
- Plant pathogenic bacterium can rapidly evolve tolerance to an antimicrobial plant allelochemical.Evolutionary applications · 2022Article
- Sulforaphane and Its Bifunctional Analogs: Synthesis and Biological Activity.Molecules (Basel, Switzerland) · 2022Review
- Transcriptomic Reprograming ofPlants (Basel, Switzerland) · 2021Article
- Sulforaphane alters the acidification of the yeast vacuole.Microbial cell (Graz, Austria) · 2020Article
- Antibiotic and Antibiofilm Activities ofPathogens (Basel, Switzerland) · 2020Article
- Phytochemicals as alternatives to antibiotics against major pathogens involved in bovine respiratory disease(BRD)and bovine mastitis(BM).Bioinformation · 2019Article
- Functional Profiling and Crystal Structures of Isothiocyanate Hydrolases Found in Gut-Associated and Plant-Pathogenic Bacteria.Applied and environmental microbiology · 2018Article
- Isothiocyanates: An Overview of Their Antimicrobial Activity against Human Infections.Molecules (Basel, Switzerland) · 2018Review
- Ellagitannin HeT obtained from strawberry leaves is oxidized by bacterial membranes and inhibits the respiratory chain.FEBS open bio · 2018Article
- Antimicrobial Activity and Chromatographic Analysis of Extracts from Tropaeolum pentaphyllum Lam. Tubers.Molecules (Basel, Switzerland) · 2016Article
- Isothiocyanates as effective agents against enterohemorrhagic Escherichia coli: insight to the mode of action.Scientific reports · 2016Article
- Antibiotic resistance modulation and modes of action of (-)-α-pinene in Campylobacter jejuni.PloS one · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Campylobacter jejuni is a widespread pathogen responsible for most of the food-borne gastrointestinal diseases in Europe. The use of natural antimicrobial molecules is a promising alternative to antibiotic treatments for pathogen control in the food industry. Isothiocyanates are natural antimicrobial compounds, which also display anticancer activity. Several studies described the chemoprotective effect of isothiocyanates on eukaryotic cells, but the antimicrobial mechanism is still poorly understood. We investigated the early cellular response of C. jejuni to benzyl isothiocyanate by both transcriptomic and physiological approaches. The transcriptomic response of C. jejuni to benzyl isothiocyanate showed upregulation of heat shock response genes and an impact on energy metabolism. Oxygen consumption was progressively impaired by benzyl isothiocyanate treatment, as revealed by high-resolution respirometry, while the ATP content increased soon after benzyl isothiocyanate exposition, which suggests a shift in the energy metabolism balance. Finally, benzyl isothiocyanate induced intracellular protein aggregation. These results indicate that benzyl isothiocyanate affects C. jejuni by targeting proteins, resulting in the disruption of major metabolic processes and eventually leading to cell death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.