Evidence map›Paper›PMID 24014504›Full record

ArticleNeurology2013

Epstein-Barr virus in oral shedding of children with multiple sclerosis.

Carmen Yea, Raymond Tellier, Patrick Chong, Garrett Westmacott, Ruth Ann Marrie, Amit Bar-Or, Brenda Banwell, Canadian Pediatric Demyelinating Disease Network

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

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  14. Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection.Proceedings of the National Academy of Sciences of the United States of America · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Carmen YeaFrom Neuroscience and Mental Health, Research Institute (C.Y.), The Hospital for Sick Children, Toronto; the Department of Microbiology, Immunology, and Infectious Diseases (R.T.), University of Calgary; the Provincial Public Health Laboratory of Alberta (R.T.), Calgary; the National Microbiology Laboratory (P.C., G.W.), Public Health Agency of Canada, Winnipeg; the Department of Internal Medicine (R.A.M.), University of Manitoba, Winnipeg; the Experimental Therapeutics Program (A.B.-O.), Montreal Neurological Institute, McGill University, Montreal, Canada; and the Division of Neurology (B.B.), The Children's Hospital of Philadelphia, PA.
Raymond Tellier
Patrick Chong
Garrett Westmacott
Ruth Ann Marrie
Amit Bar-Or
Brenda Banwell
Canadian Pediatric Demyelinating Disease Network
McGill University · CAProvincial Laboratory of Public Health · CAPublic Health LaboratoryUniversity of Calgary · CAUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate Epstein-Barr virus (EBV) oral shedding frequency and EBV genetic diversity in pediatric patients with multiple sclerosis (MS).

methodsThis was a prospective case-control study. We used PCR-based assays to detect viral DNA in the monthly mouth swabs of 22 pediatric patients with MS and 77 age- and sex-matched healthy controls. EBV-positive samples were further analyzed for sequence variation in the EBV BCRF1 (ebvIL-10) gene using direct DNA sequencing methods, and in the EBV LMP1 gene by mass spectrometry.

resultsNineteen of the 22 (86.4%) children with MS were seropositive for remote EBV infection compared to 35 out of 77 (45.5%) healthy controls (p = 0.008). Baseline analysis of mouth swabs revealed a higher proportion of EBV-positive samples from EBV-seropositive patients with MS compared to EBV-seropositive healthy controls (52.6% vs 20%, p = 0.007). Longitudinal analysis of monthly swabs revealed average EBV detection rates of 50.6% in patients with MS and 20.4% in controls (p = 0.01). The oral shedding frequencies of Herpesviruses herpes simplex virus-1, cytomegalovirus, human herpesvirus (HHV)-6, and HHV-7 did not differ between groups. Changes in the predominant EBV genetic variants were detected more frequently in patients with MS; however, no specific EBV genetic variant was preferentially associated with MS.

conclusionChildren with MS demonstrate abnormally increased rates of EBV viral reactivation and a broader range of genetic variants, suggesting a selective impairment in their immunologic control of EBV.

Indexed as

AdolescentCase-Control StudiesChildComorbidityEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHumansMaleMultiple Sclerosis, Relapsing-RemittingProspective StudiesViral Matrix ProteinsViral ProteinsVirus SheddingBCRF1 protein, Human herpesvirus 4EBV-associated membrane antigen, Epstein-Barr virusViral Matrix ProteinsViral Proteins

Identifiers

PMID24014504
PMCPMC3806908
OpenAlexW2134221130

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.