ReviewWiley interdisciplinary reviews. Developmental biology2013
Birth defects associated with perturbations in preimplantation, gastrulation, and axis extension: from conjoined twinning to caudal dysgenesis.
Review in Wiley interdisciplinary reviews. Developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- FATE-MAP predicts teratogenicity and human gastrulation failure modes by integrating deep learning and mechanistic modeling.Nature communications · 2026Article
- Low-level tetrabromobisphenol A (TBBPA) exposure disrupts early embryonic architecture: molecular impacts on dorsoventral patterning.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2026Article
- Primitive means first, not worst: Critical roles for primitive endoderm in embryos and embryo models.Developmental biology · 2025Review
- Signaling Centers Drive Brachyury Dynamics and Lineage Commitment in mESC Aggregates.FASEB bioAdvances · 2025Article
- An explainable map of human gastruloid morphospace reveals gastrulation failure modes and predicts teratogens.bioRxiv : the preprint server for biology · 2024Article
- Season, household registry and isolated birth defects: a population-based case-control study in Danyang, China.International health · 2024Article
- The migration pattern of cells during the mesoderm and endoderm differentiation from human pluripotent stem cells.In vitro cellular & developmental biology. Animal · 2024Article
- Interspecies control of development during mammalian gastrulation.Emerging topics in life sciences · 2023Review
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- Article
- Gastrulation and Body Axes Formation: A Molecular Concept and Its Clinical Correlates.The Malaysian journal of medical sciences : MJMS · 2022Review
- Ubiquitin ligases: guardians of mammalian development.Nature reviews. Molecular cell biology · 2022Review
- Cell-state transitions and collective cell movement generate an endoderm-like region in gastruloids.eLife · 2022Article
- Mermaid syndrome: A case report in Somalia.Annals of medicine and surgery (2012) · 2022Article
- Unifying synthetic embryology.Developmental biology · 2021Article
- Biomedical and societal impacts of in vitro embryo models of mammalian development.Stem cell reports · 2021Review
- Gastrulation : Current Concepts and Implications for Spinal Malformations.Journal of Korean Neurosurgical Society · 2021Article
- Caudal Regression Syndrome.Children (Basel, Switzerland) · 2020Article
- A tale of two cell-fates: role of the Hippo signaling pathway and transcription factors in early lineage formation in mouse preimplantation embryos.Molecular human reproduction · 2020Review
- Descriptive and risk factor analysis of nonsyndromic sacral agenesis: National Birth Defects Prevention Study, 1997-2011.American journal of medical genetics. Part A · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Congenital malformations represent approximately 3 in 100 live births within the human population. Understanding their pathogenesis and ultimately formulating effective treatments are underpinned by knowledge of the events and factors that regulate normal embryonic development. Studies in model organisms, primarily in the mouse, the most prominent genetically tractable mammalian model, have equipped us with a rudimentary understanding of mammalian development from early lineage commitment to morphogenetic processes. In this way, information provided by studies in the mouse can, in some cases, be used to draw parallels with other mammals, including human. Here, we provide an overview of our current understanding of the general sequence of developmental events from early cell cleavages to gastrulation and axis extension occurring in human embryos. We will also review some of the rare birth defects occurring at these stages, in particular those resulting in conjoined twinning or caudal dysgenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.