Evidence map›Paper›PMID 24014169›Full record

ArticleAngewandte Chemie (International ed. in English)2013

Structure-based gene targeting discovery of sphaerimicin, a bacterial translocase I inhibitor.

Masanori Funabashi, Satoshi Baba, Toshio Takatsu, Masaaki Kizuka, Yasuo Ohata, Masahiro Tanaka, Koichi Nonaka, Anatol P Spork, Christian Ducho, Wei-Chen Leyla Chen and 1 more

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Natural product reports · 2023
    Review
  3. Biosynthesis and Genome Mining Potentials of Nucleoside Natural Products.Chembiochem : a European journal of chemical biology · 2023
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Oligonucleotide analogues with cationic backbone linkages.Beilstein journal of organic chemistry · 2018
    Review
  13. Review
  14. Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes.Journal of industrial microbiology & biotechnology · 2016
    Review
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Masanori FunabashiNatural Product Research Group, Discovery Science and Technology Department, Drug Discovery and Biomedical Technology Unit, Daiichi Sankyo RD Novare Co., Ltd. Tokyo 134-8630 (Japan).
Satoshi Baba
Toshio Takatsu
Masaaki Kizuka
Yasuo Ohata
Masahiro Tanaka
Koichi Nonaka
Anatol P Spork
Christian Ducho
Wei-Chen Leyla Chen
Steven G Van Lanen

Funding

Biosynthesis of nucleoside antibiotics targeting bacterial translocase IR01AI087849 · NIAID · UNIVERSITY OF KENTUCKY · PI VAN LANEN, STEVEN GARY · 2011 to 2020
$3.3M
NIAID NIH HHS AI087849NIAID NIH HHS R01 AI087849
6 · The paper itself

Abstract

Rise and shine: Using a gene-targeting approach aimed at identifying potential L-threonine:uridine-5'-transaldolases that catalyze the formation of (5'S,6'S)-C-glycyluridine, a new bacterial translocase I inhibitor was discovered from an actinomycete following fermentation optimization.

Indexed as

ActinobacteriaAnti-Bacterial AgentsEnzyme InhibitorsGene TargetingTransaldolaseAnti-Bacterial AgentsEnzyme InhibitorsTransaldolaseactinomycetesbacterial translocase I inhibitorgene targetingnucleoside antibioticstransaldolase

Identifiers

PMID24014169
PMCPMC3873198

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.